{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:13:33Z","timestamp":1790230413076,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T00:00:00Z","timestamp":1511395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"MSIP","doi-asserted-by":"publisher","award":["2015R1C1A2A01054507"],"award-info":[{"award-number":["2015R1C1A2A01054507"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A2B2006694"],"award-info":[{"award-number":["2017R1A2B2006694"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> In addition to Lewy body pathology, amyloid\u2010\u03b2 plaques and neurofibrillary tangles that are characteristic for Alzheimer's disease are also frequently found in Lewy body diseases.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> The objective of this study was to investigate tau accumulation patterns in dementia with Lewy bodies and other Lewy body diseases using in vivo <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 PET.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study included 12 Parkinson's disease (PD) patients with normal cognition, 22 PD patients with cognitive impairment, and 18 dementia with Lewy bodies patients. In addition, 25 Alzheimer's disease patients and 25 healthy controls were included for comparison. All participants underwent <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 and <jats:sup>18<\/jats:sup>F\u2010florbetaben PET scans, and cortical binding values were compared between the controls and each disease group.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> When compared with the controls, dementia with Lewy bodies patients showed slightly increased <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 binding in the primary sensorimotor and visual cortices and the parieto\u2010temporal cortices, which failed to survive multiple comparisons. Amyloid\u2010positive dementia with Lewy bodies patients showed significantly increased binding in the same regions when compared with controls, and even greater binding in the primary sensorimotor and visual cortices than Alzheimer's disease. Meanwhile, binding in the lateral and medial temporal cortices was less prominent than in Alzheimer's disease. In dementia with Lewy bodies, <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 binding in the occipital cortex correlated with <jats:sup>18<\/jats:sup>F\u2010florbetaben binding. Amyloid\u2010negative patients with normal cognition, patients with cognitive impairment, and dementia with Lewy bodies patients did not show increased <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 binding.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Dementia with Lewy bodies patients may harbor <jats:sup>18<\/jats:sup>F\u2010AV\u20101451 binding patterns distinct from Alzheimer's disease, with greater involvement of the primary cortices and less involvement of the temporal cortex. Tau burden increases in the Lewy body disease spectrum, and amyloid may play an important role in the accumulation of neocortical tau in Lewy body diseases. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27252","type":"journal-article","created":{"date-parts":[[2017,11,23]],"date-time":"2017-11-23T08:22:44Z","timestamp":1511425364000},"page":"262-272","source":"Crossref","is-referenced-by-count":65,"title":["Distinct patterns of amyloid\u2010dependent tau accumulation in Lewy body diseases"],"prefix":"10.1002","volume":"33","author":[{"given":"Seung Ha","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Yong","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"},{"name":"Division of RI\u2010Convergence Research Korea Institute Radiological and Medical Sciences Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hyoung","family":"Lyoo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gangnam Severance Hospital Yonsei University College of Medicine Seoul Republic of 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