{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:15:24Z","timestamp":1783041324201,"version":"3.54.6"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["P2GEP3_151597"],"award-info":[{"award-number":["P2GEP3_151597"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> We investigated the acute effect of short pulse widths on the therapeutic window in subthalamic nucleus deep brain stimulation in Parkinson's disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We assessed 10 PD patients with STN\u2010DBS at a 60\u2010\u00b5s pulse width. We randomly and double\u2010blindedly applied 10\u2010 to 50\u2010\u00b5s pulse widths. The principal outcome was the therapeutic window (difference between the amplitude thresholds for visible muscle contraction and for best rigidity control). The secondary outcome was the charge per pulse (which reflects the efficiency of the stimulation) needed to control rigidity. Two\u2010way analysis of variance and pairwise <jats:italic>t<\/jats:italic> tests were applied.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The therapeutic window widened when the pulse width shortened (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.45; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and charge per pulse was reduced (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This randomized, double\u2010blind study showed that shorter pulse widths widen the therapeutic window of STN\u2010DBS in PD without increasing the electrical charge required to obtain the same acute clinical benefit. \u00a9 2017 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27265","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T18:34:10Z","timestamp":1513881250000},"page":"169-173","source":"Crossref","is-referenced-by-count":34,"title":["Short pulse width in subthalamic stimulation in Parkinson's disease: a randomized, double\u2010blind study"],"prefix":"10.1002","volume":"33","author":[{"given":"Walid","family":"Bouthour","sequence":"first","affiliation":[{"name":"Department of Neurology Geneva University Hospital Geneva Switzerland"},{"name":"Department of Basic Neuroscience University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wegrzyk","sequence":"additional","affiliation":[{"name":"Department of Neurology Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahan","family":"Momjian","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Geneva University Hospital Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"P\u00e9ron","sequence":"additional","affiliation":[{"name":"Department of Neurology Geneva University Hospital Geneva 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