{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:09:44Z","timestamp":1790665784716,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. 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The objective of this study was to evaluate the effects of multitarget transcranial direct current stimulation of the primary motor cortex and left dorsolateral prefrontal cortex on freezing of gait and related outcomes.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twenty patients with Parkinson's disease and freezing of gait received 20 minutes of transcranial direct current stimulation on 3 separate visits. Transcranial direct current stimulation targeted the primary motor cortex and left dorsolateral prefrontal cortex simultaneously, primary motor cortex only, or sham stimulation (order randomized and double\u2010blinded assessments). Participants completed a freezing of gait\u2010provoking test, the Timed Up and Go, and the Stroop test before and after each transcranial direct current stimulation session.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Performance on the freezing of gait\u2010provoking test (<jats:italic>P<\/jats:italic>\u2009=\u20090.010), Timed Up and Go (<jats:italic>P<\/jats:italic>\u2009=\u20090.006), and the Stroop test (<jats:italic>P<\/jats:italic>\u2009=\u20090.016) improved after simultaneous stimulation of the primary motor cortex and left dorsolateral prefrontal cortex, but not after primary motor cortex only or sham stimulation.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Transcranial direct current stimulation designed to simultaneously target motor and cognitive regions apparently induces immediate aftereffects in the brain that translate into reduced freezing of gait and improvements in executive function and mobility. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27300","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T05:42:56Z","timestamp":1518500576000},"page":"642-646","source":"Crossref","is-referenced-by-count":139,"title":["Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Moria","family":"Dagan","sequence":"first","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Herman","sequence":"additional","affiliation":[{"name":"Center for the Study of Movement, Cognition and Mobility, Neurological Institute, Tel Aviv Sourasky Medical Center Tel Aviv 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