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Thus, the longitudinal study of carriers, and the identification of potential biomarkers and prodromal states, is essential. Here we present results of baseline assessments from an ongoing longitudinal project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The cohort consisted of 73 men, 48 with the fragile X mental retardation 1 (<jats:italic>FMR1<\/jats:italic>) premutation (55\u2010200 cytosine\u2010cytosine\u2010guanine or CGG repeats) and 25 well\u2010matched controls (&lt; 40 repeats) aged between 40 and 75 years. At enrollment, none met criteria for FXTAS or had any clinically significant tremor or ataxia by blinded neurological examination. The battery consisted of measures of visual memory, spatial working memory, response inhibition, motor speed and control, planning and problem solving, sustained attention, and a standardized movement disorder evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Contrary to expectations, there were no significant differences between premutation carriers and controls on any measure of executive function. However, the premutation carriers had significantly longer manual movement and reaction times than controls, and the significant interaction between CGG repeat and age revealed the slowest movement times among older carriers with higher CGG repeat alleles. A subset of premutation carriers had marginally lower scores on the ataxia evaluation, and they performed no differently from controls on the parkinsonism assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early\u2010developing cerebellar or fronto\u2010motor tract white matter changes, previously documented in MRI studies, may underlie motor slowing that occurs before clinically observable neurological symptoms associated with FXTAS. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27314","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T09:02:46Z","timestamp":1517475766000},"page":"628-636","source":"Crossref","is-referenced-by-count":16,"title":["Age\u2010 and CGG repeat\u2010related slowing of manual movement in fragile X carriers: A prodrome of fragile X\u2010associated tremor ataxia syndrome?"],"prefix":"10.1002","volume":"33","author":[{"given":"Ryan","family":"Shickman","sequence":"first","affiliation":[{"name":"MIND Institute University of California Davis Medical Center Sacramento California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Famula","sequence":"additional","affiliation":[{"name":"MIND Institute University of California Davis Medical Center Sacramento California USA"},{"name":"Department of Psychiatry and Behavioral Sciences University of California Davis School of Medicine Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flora","family":"Tassone","sequence":"additional","affiliation":[{"name":"MIND Institute University of California Davis Medical Center Sacramento California USA"},{"name":"Department of Biochemistry and Molecular 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