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Autonomic dysfunction, including cardiac sympathetic denervation, has been reported in familial forms of synucleinopathies that have Lewy bodies at the core of their pathogenesis. <jats:italic>SNCA<\/jats:italic> mutations and multiplications, <jats:italic>LRRK2<\/jats:italic> disease with Lewy bodies as well as other common, sporadic forms of idiopathic PD, MSA, pure autonomic failure, and dementia with Lewy bodies have all been associated with dysautonomia. By contrast, in familial cases of parkinsonism without Lewy bodies, such as in <jats:italic>PARK2<\/jats:italic>, the autonomic profile remains normal throughout the course of the disease. The degeneration of the central and peripheral autonomic systems in genetic as well as sporadic forms of neurodegenerative synucleinopathies correlates with the accumulation of alpha\u2010synuclein immunoreactive\u2010containing inclusions. Given that dysautonomia has a significant impact on the quality of life of sufferers and autonomic symptoms are generally treatable, a prompt diagnostic testing and treatment should be provided. Moreover, new evidence suggests that autonomic dysfunction can be used as an outcome prediction factor in some forms of synucleinopathies or premotor diagnostic markers that could be used in the future to define further research avenues. In this review, we describe the autonomic dysfunction of genetic synucleinopathies in comparison to the dysautonomia of sporadic forms of alpha\u2010synuclein accumulation and provide the reader with an up\u2010to\u2010date overview of the current understanding in this fast\u2010growing field. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27343","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T23:05:28Z","timestamp":1520291128000},"page":"359-371","source":"Crossref","is-referenced-by-count":27,"title":["Autonomic dysfunction in genetic forms of synucleinopathies"],"prefix":"10.1002","volume":"33","author":[{"given":"Viorica","family":"Chelban","sequence":"first","affiliation":[{"name":"Department of Molecular Neuroscience UCL Institute of Neurology, London, United Kingdom, and National Hospital for Neurology and Neurosurgery London United Kingdom"},{"name":"Department of Neurology and Neurosurgery 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