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This puzzling clinical observation questions the traditional definition of tics as purely involuntary motor behaviors. Importantly, it suggests novel insights into tic pathophysiology. In this review, we first define voluntary inhibitory tic control and compare it with other notions of tic control from the literature. We then examine the association between voluntary inhibitory tic control with premonitory urges and review evidence linking voluntary tic inhibition to other forms of executive control of action. We discuss the somatotopic selectivity and the neural correlates of voluntary inhibitory tic control. Finally, we provide a scientific framework with regard to the clinical relevance of the study of voluntary inhibitory tic control within the context of the neurodevelopmental disorder of Tourette syndrome. We identify current knowledge gaps that deserve attention in future research. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27346","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T06:37:40Z","timestamp":1520318260000},"page":"937-946","source":"Crossref","is-referenced-by-count":54,"title":["Voluntary inhibitory motor control over involuntary tic movements"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-8530","authenticated-orcid":false,"given":"Christos","family":"Ganos","sequence":"first","affiliation":[{"name":"Department of Neurology, Charit\u00e9 University Medicine Berlin Germany"},{"name":"Institute of Cognitive Neuroscience University College London London UK"},{"name":"Sobell Department of Motor Neuroscience and Movement Disorders, University College London Institute of Neurology University College London London 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