{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:51:52Z","timestamp":1789195912111,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T00:00:00Z","timestamp":1526860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: Impaired inhibitory control is thought to be a core deficit in psychiatric disorders where patients exhibit problems with controlling urges. These problems include the urge to perform movements typical of Tourette syndrome and the urge to execute compulsive actions typical of obsessive\u2010compulsive disorder. However, the picture emerging from studies that address this issue is controversial. Furthermore, most studies have only focused on reactive control (the ability of subjects to react to a stop signal), but not on proactive control (the ability of patients to shape their response strategies in anticipation of known task demands).<\/jats:p><jats:p><jats:bold>Objectives<\/jats:bold>: We assessed reactive and proactive inhibitory control in drug na\u00efve children\/adolescents affected by Tourette syndrome, obsessive\u2010compulsive disorder, and in those in which the 2 disorders co\u2010occur.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: Reaching version of the stop signal task and of a simple reaction time task were given to 37 unmedicated patients (mean age\u2009\u00b1\u2009SD, 11.0\u2009\u00b1\u20092.3) and to 37 healthy age\u2010 and gender\u2010matched controls (mean age\u2009\u00b1\u2009SD, 10.8\u2009\u00b1\u20091.6).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: Both reactive and proactive inhibition scaled with the severity of obsessive\u2010compulsive symptoms, but not with those of tic symptoms (ie, inhibitory control in uncomplicated Tourette patients was comparable with that of healthy controls).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: We suggest that the cognitive mechanisms underlying tics and compulsions controls are likely to be different. Possibly the preserved ability to suppress actions in uncomplicated Tourette patients allows them to experience a greater feeling of self\u2010control, and this fact might play a key role in evolution of the disorder beyond adolescence. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27406","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T04:55:00Z","timestamp":1526878500000},"page":"950-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Inhibition is impaired in children with obsessive\u2010compulsive symptoms but not in those with tics"],"prefix":"10.1002","volume":"33","author":[{"given":"Christian","family":"Mancini","sequence":"first","affiliation":[{"name":"Department of Anatomy, Histology, Forensic Medicine &amp; Orthopedics Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Baglioni","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Panunzi","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience Sapienza University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Pantano","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience Sapienza University Rome Italy"},{"name":"Istituto di ricovero e cura a carattere scientifico (IRCCS) Neuromed, Pozzilli (IS)  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Suppa","sequence":"additional","affiliation":[{"name":"Department of Human Neuroscience Sapienza University Rome Italy"},{"name":"Istituto di ricovero e cura a carattere scientifico (IRCCS) Neuromed, Pozzilli (IS)  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4405-2609","authenticated-orcid":false,"given":"Giovanni","family":"Mirabella","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology, Forensic Medicine &amp; 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