{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:24:36Z","timestamp":1784690676706,"version":"3.55.0"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,15]],"date-time":"2018-09-15T00:00:00Z","timestamp":1536969600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007173","name":"Bio-oriented Technology Research Advancement Institution","doi-asserted-by":"publisher","award":["16dm0207022h003"],"award-info":[{"award-number":["16dm0207022h003"]}],"id":[{"id":"10.13039\/501100007173","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>: Musician's dystonia critically impacts professional musicians' careers as they may lose musical skills, which have been acquired through long and intensive training. Yet the pathophysiology of musician's dystonia and its link to the neural mechanisms supporting musical skills is poorly understood. We tested if resting\u2010state functional connectivity might reflect an aspect of musical skill linked to the pathophysiology of musician's dystonia. We also tested a second hypothesis that the region with altered resting\u2010state functional connectivity might be correlated with a quantitative measure of musical skills.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: We studied 21 patients with musician's dystonia affecting their hands and 34 healthy musicians, using resting\u2010state functional magnetic resonance imaging and behavioral assessment. We tested between\u2010group differences of resting\u2010state functional connectivity throughout the whole brain using independent component analysis.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: We found abnormal basal ganglia resting\u2010state functional connectivity in the putamina of patients with musician's dystonia compared with those of healthy musicians (<jats:italic>P<\/jats:italic>\u2009=\u20090.035 corrected for multiple comparisons). We also found that the temporal precision of keystrokes was correlated with basal ganglia functional connectivity in the putamina of healthy pianists (<jats:italic>r<\/jats:italic>\u2009=\u20090.72, <jats:italic>P<\/jats:italic>\u2009=\u20090.0005), but not in pianists with musician's dystonia (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.11, <jats:italic>P<\/jats:italic>\u2009=\u20090.64).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: We show that abnormalities of the putamen exist even at rest in musician's dystonia, whereas putaminal abnormality has previously been reported during a task. Moreover, basal ganglia resting\u2010state functional connectivity in the putamen represented training levels in healthy musicians, and its disruption was associated with musician's dystonia. This novel finding hints at the pathophysiological mechanisms by which musician's dystonia follows extensive musical training. \u00a9 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p>","DOI":"10.1002\/mds.27448","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T09:07:29Z","timestamp":1537088849000},"page":"1472-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Resting\u2010state basal ganglia network codes a motor musical skill and its disruption From dystonia"],"prefix":"10.1002","volume":"33","author":[{"given":"Kahori","family":"Kita","sequence":"first","affiliation":[{"name":"Center for Frontier Medical Engineering Chiba University  Chiba Japan"},{"name":"Department of Advanced Neuroimaging, Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslav","family":"Rokicki","sequence":"additional","affiliation":[{"name":"NORMENT, KG Jebsen Centre for Psychosis Research, Department of Psychology University of Oslo  Oslo Norway"},{"name":"Department of Clinical Neuroimaging, Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-6645","authenticated-orcid":false,"given":"Shinichi","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Advanced Neuroimaging, Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Tokyo Japan"},{"name":"Musical Skill and Injury Center Sophia University  Tokyo Japan"},{"name":"Sony Computer Science Laboratories  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hanakawa","sequence":"additional","affiliation":[{"name":"Department of Advanced Neuroimaging, Integrative Brain Imaging Center National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2010.08.025"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.12.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.38.7.1005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000345670.63363.d1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2014.05.014"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00422-014-0631-5"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0615"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh402"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20113"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199811160-00006"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl181"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.08.023"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25029"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-307127"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21250"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26893"},{"key":"e_1_2_5_20_1","volume-title":"Neuroscience","author":"Kita K","year":"2016"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.01.026"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80028-6"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(08)60347-5"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.10.017"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0255-z"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078234"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.05.025"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1973.tb00801.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-14-133"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37632"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.11.046"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2003.822821"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1635"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.185637"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150170263"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5468-9"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21626"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.53.1.96"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.01.060"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.03.061"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.066"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/105.3.461"},{"key":"e_1_2_5_43_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.21091\/mppa.2010.1002","article-title":"Focal dystonia in musicians: phenomenology, pathophysiology, triggering factors, and treatment","volume":"25","author":"Altenm\u00fcller E","year":"2010","journal-title":"Med Probl Perform Art"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21976"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.3931"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20108"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.06.035"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn083"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg267"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.04.033"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90107-L"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2011.245811"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs083"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2008.01.005"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4570-14.2015"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.27448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1002%2Fmds.27448","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:55:25Z","timestamp":1760961325000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.27448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/mds.27448"],"URL":"https:\/\/doi.org\/10.1002\/mds.27448","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"2017-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}