{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:36:55Z","timestamp":1780677415192,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["PPMI"],"award-info":[{"award-number":["PPMI"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Background:<\/jats:bold> The p.A53T point mutation in the \u03b1\u2010synuclein gene (<jats:italic>SNCA<\/jats:italic>) is a rare but highly relevant cause of autosomal dominant Parkinson's disease (PD).<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> The objective of this study was to assess striatal dopaminergic denervation in a cohort of symptomatic carriers of the p.A53T <jats:italic>SNCA<\/jats:italic> mutation as compared to PD patients.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Data from the Parkinson's Progression Markers Initiative database of 11 symptomatic p.A53T <jats:italic>SNCA<\/jats:italic> mutation carriers who underwent 123I\u2010FP\u2010CIT SPECT [(123) I\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010N\u2010(3\u2010fluoropropyl) nortropane single photon emission computed tomography] imaging at our site were compared with those of 33 age\u2010, sex\u2010, and disease duration\u2013matched PD patients.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The p.A53T mutation carriers had significantly lower caudate nucleus binding ratio both contralaterally and ipsilaterally to the most affected side (<jats:italic>P<\/jats:italic>\u2009=\u2009.002 and <jats:italic>P<\/jats:italic>\u2009=\u2009.006) and a decreased contralateral caudate\/putamen signal ratio (<jats:italic>P<\/jats:italic>\u2009=\u2009.007) as compared to PD. A similar degree of striatal asymmetry was observed in both subgroups. No correlation between scores in neuropsychological tests and caudate nucleus dopaminergic denervation could be demonstrated.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> PD patients harboring the p.A53T <jats:italic>SNCA<\/jats:italic> mutation show evidence of a more severe nigrostriatal denervation, especially evident in the caudate nucleus. The lack of significant differences in the putaminal binding ratios may reflect a floor effect or a true preferential targeting of the caudate terminals in p.A53T <jats:italic>SNCA<\/jats:italic>\u2010associated PD. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27451","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T23:22:21Z","timestamp":1538781741000},"page":"1734-1739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["123I\u2010FP\u2010CIT SPECT [(123) I\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010N\u2010(3\u2010fluoropropyl) nortropane single photon emission computed tomography] Imaging in a p.A53T \u03b1\u2010synuclein Parkinson's disease cohort versus Parkinson's disease"],"prefix":"10.1002","volume":"33","author":[{"given":"Christos","family":"Koros","sequence":"first","affiliation":[{"name":"1st Neurology Clinic, Eginition Hospital Athens University Medical School  Athens Greece"},{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Simitsi","sequence":"additional","affiliation":[{"name":"1st Neurology Clinic, Eginition Hospital Athens University Medical School  Athens Greece"},{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Prentakis","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit Attikon Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Beratis","sequence":"additional","affiliation":[{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Papadimitriou","sequence":"additional","affiliation":[{"name":"Neurology Clinic Henry Dunan Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dionysia","family":"Kontaxopoulou","sequence":"additional","affiliation":[{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Fragkiadaki","sequence":"additional","affiliation":[{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Papagiannakis","sequence":"additional","affiliation":[{"name":"2nd Neurology Clinic, Attikon Hospital Athens University Medical School  Athens 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