{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:40:53Z","timestamp":1791164453111,"version":"4.1.0"},"reference-count":165,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T00:00:00Z","timestamp":1538092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"LSVT Global, Inc., Tucson, Arizona"},{"name":"National Institutes of Health-National Institute of Deafness and Other Communication Disorders","award":["R01 DC01150"],"award-info":[{"award-number":["R01 DC01150"]}]},{"name":"LSVT Global, Inc."},{"name":"National Institutes of Health-National Institute of Deafness and Other Communication Disorders","award":["R01 DC01150"],"award-info":[{"award-number":["R01 DC01150"]}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>As many as 89% of people with Parkinson's disease (PD) develop speech disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This randomized controlled trial evaluated two speech treatments for PD matched in intensive dosage and high\u2010effort mode of delivery, differing in subsystem target: voice (respiratory\u2010laryngeal) versus articulation (orofacial\u2010articulatory).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PD participants were randomized to 1\u2010month LSVT LOUD (voice), LSVT ARTIC (articulation), or UNTXPD (untreated) groups. Speech clinicians specializing in PD delivered treatment. Primary outcome was sound pressure level (SPL) in reading and spontaneous speech, and secondary outcome was participant\u2010reported Modified Communication Effectiveness Index (CETI\u2010M), evaluated at baseline, 1, and 7 months. Healthy controls were matched by age and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At baseline, the combined PD group (n = 64) was significantly worse than healthy controls (n = 20) for SPL (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) and CETI\u2010M (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0001). At 1 and 7 months, SPL between\u2010group comparisons showed greater improvements for LSVT LOUD (n = 22) than LSVT ARTIC (n = 20;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05) and UNTXPD (n = 22;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.05). Sound pressure level differences between LSVT ARTIC and UNTXPD at 1 and 7 months were not significant (\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05). For CETI\u2010M, between\u2010group comparisons showed greater improvements for LSVT LOUD and LSVT ARTIC than UNTXPD at 1 month (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.02). At 7 months, CETI\u2010M between\u2010group differences were not significant (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.08). Within\u2010group CETI\u2010M improvements for LSVT LOUD were maintained through 7 months (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LSVT LOUD showed greater improvements than both LSVT ARTIC and UNTXPD for SPL at 1 and 7 months. For CETI\u2010M, both LSVT LOUD and LSVT ARTIC improved at 1 month relative to UNTXPD. Only LSVT LOUD maintained CETI\u2010M improvements at 7 months. \u00a9 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.27460","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T06:11:26Z","timestamp":1538115086000},"page":"1777-1791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":211,"title":["Speech treatment in Parkinson's disease: Randomized controlled trial (RCT)"],"prefix":"10.1002","volume":"33","author":[{"given":"Lorraine","family":"Ramig","sequence":"first","affiliation":[{"name":"University of Colorado\u2010Boulder  Boulder Colorado USA"},{"name":"National Center for Voice and Speech\u2010Denver  Denver Colorado USA"},{"name":"Columbia University\u2010New York City  New York New York USA"},{"name":"LSVT Global, Inc.\u2010Tucson  Tucson Arizona 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