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However, distinguishing functional disability related to cognition from that attributed to motor symptoms can be difficult in PD. A performance\u2010based functional assessment allows for direct observation of activity of daily living skills and separation of cognitive from motoric disabilities.<\/jats:p><jats:p><jats:bold>Objectives:<\/jats:bold> Validate the University of California San Diego Performance\u2010Based Skills Assessment in PD.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold>: One hundred PD participants, ranging from normal cognition to dementia, completed the University of California San Diego Performance\u2010Based Skills Assessment, a performance\u2010based measure of cognitively demanding activities of daily living, as well as a neuropsychological battery and motor examination. Cognitive classification was determined by consensus conference, blinded to University of California San Diego Performance\u2010Based Skills Assessment scores. Psychometric properties of the University of California San Diego Performance\u2010Based Skills Assessment, including internal consistency, test\u2010retest and inter\u2010rater reliability, and discriminant validity for dementia, were examined.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>: The University of California San Diego Performance\u2010Based Skills Assessment demonstrated strong internal consistency (Cronbach's \u03b1\u2009=\u20090.82) and test\u2010retest reliability (r\u2009=\u20090.89) and correlated strongly with global cognition (Mattis Dementia Rating Scale: r\u2009=\u20090.80; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). University of California San Diego Performance\u2010Based Skills Assessment regression models indicated greater contribution from cognitive explanatory variables (marginal partial: R<jats:sup>2<\/jats:sup>\u2009=\u20090.33) than motor variables (marginal partial: R<jats:sup>2<\/jats:sup>\u2009=\u20090.05), controlling for age, education, disease duration, and <jats:sc>l<\/jats:sc>\u2010dopa equivalent dose. Additionally, the University of California San Diego Performance\u2010Based Skills Assessment exhibited strong discriminant validity for dementia (area under the curve\u2009=\u20090.91).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>: The University of California San Diego Performance\u2010Based Skills Assessment is a valid measure of functional abilities related to cognition rather than motor symptoms in PD. Furthermore, it reliably distinguishes demented from nondemented participants. The University of California San Diego Performance\u2010Based Skills Assessment may be considered as an outcome measure that combines cognitive and functional abilities in treatment trials for cognitive impairment in PD. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27487","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:16:56Z","timestamp":1539217016000},"page":"1760-1768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Validation of a performance\u2010based assessment of cognitive functional ability in Parkinson's disease"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-0606","authenticated-orcid":false,"given":"Samantha K.","family":"Holden","sequence":"first","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis D.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Houston  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Hoyt","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H.","family":"Sillau","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0602-9942","authenticated-orcid":false,"given":"Brian D.","family":"Berman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Neurology Section, Denver VA Medical Center  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer G.","family":"Goldman","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Section of Parkinson's Disease and Movement Disorders Rush University Medical Center  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Parkinson's Disease and Mental Illness Research Education, Clinical and Education Centers, Corporal Michael J. 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