{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:30:59Z","timestamp":1777649459546,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T00:00:00Z","timestamp":1544400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated R2* relaxation rates as a marker of iron content in the substantia nigra in patients with common tremor disorders and explored their diagnostic properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mean nigral R2* rates were measured in 40 patients with tremor\u2010dominant Parkinson's disease (PD), 15 with tremor in dystonia, 25 with essential tremor, and 25 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tremor\u2010dominant PD patients had significantly higher nigral R2* values (34.1\u2009\u00b1\u20095.7) than those with tremor in dystonia (30.0\u2009\u00b1\u20093.9), essential tremor (30.6\u2009\u00b1\u20094.8), and controls (30.0\u2009\u00b1\u20092.8). An R2* threshold of 31.15 separated tremor\u2010dominant PD from controls with a sensitivity and specificity of 67.5% and 72%. The sensitivity and specificity for discrimination between PD and non\u2010PD tremor patients was 67.5% and 60%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron content in the substantia nigra is significantly higher in tremor\u2010dominant PD than in tremor in dystonia, essential tremor, and controls. Because of the considerable overlap, nigral R2* cannot be suggested as a useful diagnostic tool. \u00a9 2018 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27549","type":"journal-article","created":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:49:06Z","timestamp":1544460546000},"page":"129-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Nigral iron deposition in common tremor disorders"],"prefix":"10.1002","volume":"34","author":[{"given":"Nina","family":"Homayoon","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Pirpamer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical 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