{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:35:51Z","timestamp":1785875751451,"version":"3.56.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003024","name":"Shanghai Education Development Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Lymphocyte activation gene\u20103 (LAG\u20103) could mediate pathological \u03b1\u2010synuclein transmission in neurodegeneration and may be involved in the pathogenesis of Parkinson's disease (PD). The aim of the present study was to explore soluble LAG\u20103 (sLAG\u20103) as a potential diagnostic biomarker for PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum sLAG\u20103 concentrations were measured by a quantitative ELISA for patients with PD, essential tremor (ET) and age\u2010 and sex\u2010matched controls. The relationships between sLAG\u20103 and clinical phenotype were assessed via correlation analysis and logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum sLAG\u20103 levels in patients with PD were significantly higher than those in ET patients and age\u2010 and sex\u2010matched controls. The area under the curve of serum sLAG\u20103 in differentiating PD from age\u2010 and sex\u2010matched controls was 0.82. Serum sLAG\u20103 was associated with non\u2010motor symptoms and excessive daytime sleep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>sLAG\u20103 is a candidate novel biomarker for PD. \u00a9 2018 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27569","type":"journal-article","created":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T13:02:37Z","timestamp":1543410157000},"page":"138-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Serum soluble lymphocyte activation gene\u20103 as a diagnostic biomarker in Parkinson's disease: A pilot multicenter study"],"prefix":"10.1002","volume":"34","author":[{"given":"Shi\u2010shuang","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Neurology &amp; Co\u2010innovation Center of Neuroregeneration Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of 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