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Although lysosomal storage disorders are diagnosed predominantly in children, many show variable expressivity with clinical presentations possible later in life. Given the important role of lysosomes in neuronal homeostasis, neurological manifestations, including movement disorders, can accompany many lysosomal storage disorders. Over the last decade, evidence from genetics, clinical epidemiology, cell biology, and biochemistry have converged to implicate links between lysosomal storage disorders and adult\u2010onset movement disorders. The strongest evidence comes from mutations in\n                    <jats:italic>Glucocerebrosidase<\/jats:italic>\n                    , which cause Gaucher's disease and are among the most common and potent risk factors for PD. However, recently, many additional lysosomal storage disorder genes have been similarly implicated, including\n                    <jats:italic>SMPD1<\/jats:italic>\n                    ,\n                    <jats:italic>ATP13A2<\/jats:italic>\n                    ,\n                    <jats:italic>GALC<\/jats:italic>\n                    , and others. Examination of these links can offer insight into pathogenesis of PD and guide development of new therapeutic strategies. We systematically review the emerging genetic links between lysosomal storage disorders and PD. \u00a9 2019 International Parkinson and Movement Disorder Society\n                  <\/jats:p>","DOI":"10.1002\/mds.27631","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T15:09:40Z","timestamp":1549465780000},"page":"614-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Emerging links between pediatric lysosomal storage diseases and adult parkinsonism"],"prefix":"10.1002","volume":"34","author":[{"given":"Daniel","family":"Ysselstein","sequence":"first","affiliation":[{"name":"Ken and Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Departments of Neurology, Neuroscience, and 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