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Individuals negative for amyloid \u03b2 PET with [<jats:sup>11<\/jats:sup>C]Pittsburgh compound B underwent clinical scoring, MR scans, and [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3\/PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in binding potential for [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3 between PSP patients and healthy control subjects (<jats:italic>P<\/jats:italic>\u2009=\u20090.02). PSP patients exhibited greater radioligand retention than healthy control subjects in multiple brain regions, including frontoparietal white matter, parietal gray matter, globus pallidus, STN, red nucleus, and cerebellar dentate nucleus. [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3 deposition in frontoparietal white matter, but not gray matter, was correlated with general severity of parkinsonian and PSP symptoms, whereas both gray matter and white matter [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3 accumulations in the frontoparietal cortices were associated with nonverbal cognitive impairments. Autoradiographic and fluorescence labeling with pyridinyl\u2010butadienyl\u2010benzothiazole 3 was observed in gray matter and white matter of PSP motor cortex tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings support the in vivo detectability of tau fibrils characteristic of PSP by [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3\/PET, and imply distinct and synergistic contributions of gray matter and white matte tau pathologies to clinical symptoms. [<jats:sup>11<\/jats:sup>C]pyridinyl\u2010butadienyl\u2010benzothiazole 3\/PET potentially provides a neuroimaging\u2010based index for the evolution of PSP tau pathologies promoting the deterioration of motor and cognitive functions. \u00a9 2019 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27643","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T10:35:32Z","timestamp":1553078132000},"page":"744-754","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["In vivo binding of a tau imaging probe, [<sup>11<\/sup>C]PBB3, in patients with progressive supranuclear palsy"],"prefix":"10.1002","volume":"34","author":[{"given":"Hironobu","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Division of Neurology Kobe University Graduate School of Medicine  Kobe Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naruhiko","family":"Sahara","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maiko","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8868-9700","authenticated-orcid":false,"given":"Shunsuke","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Department of Psychiatry Nara Medical University  Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumitoshi","family":"Niwa","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Department of Neurology Kyoto Prefectural University of Medicine  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Department of Neurology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology  Obu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ichise","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Shinotoh","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"},{"name":"Neurology Chiba Clinic  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Rong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiopharmaceuticals Development Clinical Research Cluster, NIRS, QST  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Neurology, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsushi","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Suhara","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences (NIRS) National Institutes for Quantum and Radiological Science and Technology (QST)  Chiba Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Functional Brain Imaging Research (DOFI), Clinical Research Cluster, National Institute of Radiological Sciences 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460160003001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.11.2015"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1385\/NMM:2:2:131"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2194"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90829-X"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26844"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26727"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26813"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26834"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13164"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24844"},{"key":"e_1_2_9_15_1","first-page":"781","article-title":"18F\u2010AV\u20101451 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