{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T14:42:19Z","timestamp":1781534539534,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex difference is related to specific clinical features in PD patients over the disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the potential sex\u2010difference effect on the spontaneous neuronal activity within the most reported resting\u2010state networks in early untreated PD patients and its correlation with baseline and longitudinal clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010six drug\u2010na\u00efve PD patients (30\/26 male\/female) and 30 (15\/15 male\/female) matched controls were enrolled in the study. Topological and spectral resting\u2010state functional MRI features of the sensorimotor, dorsal and ventral attention, frontoparietal, and default\u2010mode networks were analyzed for possible sex\u2010difference effects in both PD patients and controls groups. Additionally, a region\u2010of\u2010interest analysis was performed to test for a sex effect on basal ganglia connectivity. Multivariate ordinal regression was used to investigate whether connectivity findings at baseline were predictors of motor impairment over a 2\u2010year follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to female PD patients and controls, male PD patients showed an abnormal spectral composition of the sensorimotor and dorsal attention networks in the slow\u20105 band. The region\u2010of\u2010interest analysis showed an increased connectivity within the basal ganglia in female PD patients compared to males. Functional sensorimotor connectivity changes at baseline showed to be an independent predictor of disease severity at 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings revealed the presence of a disease\u2010related, sex\u2010specific cortical and subcortical connectivity pattern within the sensorimotor network, in the early stage of PD. We hypothesize that these findings may be related to the presence of different sex\u2010specific nigrostriatal dopaminergic pathways and might predict PD progression. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27725","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T09:30:30Z","timestamp":1560159030000},"page":"997-1005","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Sex\u2010related pattern of intrinsic brain connectivity in drug\u2010na\u00efve Parkinson's disease patients"],"prefix":"10.1002","volume":"34","author":[{"given":"Rosa","family":"De Micco","sequence":"first","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u201cLuigi Vanvitelli\u201d  Napoli Italy"},{"name":"MRI Research Center, University of Campania \u201cLuigi Vanvitelli\u201d  Napoli 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