{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:51:49Z","timestamp":1790715109828,"version":"4.1.0"},"reference-count":84,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>MR\u2010guided focused ultrasound is a novel, minimally invasive surgical procedure for symptomatic treatment of PD. With this technology, the ventral intermediate nucleus, STN, and internal globus pallidus have been targeted for therapeutic cerebral ablation, while also minimizing the risk of hemorrhage and infection from more invasive neurosurgical procedures. In a double\u2010blinded, prospective, sham\u2010controlled randomized controlled trial of MR\u2010guided focused ultrasound thalamotomy for treatment of tremor\u2010dominant PD, 62% of treated patients demonstrated improvement in tremor scores from baseline to 3 months postoperatively, as compared to 22% in the sham group. There has been only one open\u2010label trial of MR\u2010guided focused ultrasound subthalamotomy for patients with PD, demonstrating improvements of 71% for rigidity, 36% for akinesia, and 77% for tremor 6 months after treatment. Among the two open\u2010label trials of MR\u2010guided focused ultrasound pallidotomy for patients with PD, dyskinesia and overall motor scores improved up to 52% and 45% at 6 months postoperatively. Although MR\u2010guided focused ultrasound thalamotomy is now approved by the U.S. Food and Drug Administration for treatment of parkinsonian tremor, additional high\u2010quality randomized controlled trials are warranted and are underway to determine the safety and efficacy of MR\u2010guided focused ultrasound subthalamotomy and pallidotomy for treatment of the cardinal features of PD. These studies will be paramount to aid clinicians to determine the ideal ablative target for individual patients. Additional work will be required to assess the durability of MR\u2010guided focused ultrasound lesions, ideal timing of MR\u2010guided focused ultrasound ablation in the course of PD, and the safety of performing bilateral lesions. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27779","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T15:14:36Z","timestamp":1562771676000},"page":"1243-1251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["The role of high\u2010intensity focused ultrasound as a symptomatic treatment for Parkinson's disease"],"prefix":"10.1002","volume":"34","author":[{"given":"Shayan","family":"Moosa","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery University of Virginia Health System  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Mart\u00ednez\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"CINAC (Centro Integral de Neurociencias) University Hospital HM Puerta del Sur, CEU\u2010San Pablo University  M\u00f3stoles Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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