{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:20:33Z","timestamp":1790180433283,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1132524"],"award-info":[{"award-number":["1132524"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1106974"],"award-info":[{"award-number":["1106974"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1079679"],"award-info":[{"award-number":["1079679"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although motor abnormalities have been flagged as potentially the most sensitive and specific clinical features for predicting the future progression to Parkinson's disease, little work has been done to characterize gait and balance impairments in idiopathic rapid eye movement sleep behavior disorder (iRBD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to quantitatively determine any static balance as well as gait impairments across the 5 independent domains of gait in polysomnography\u2010confirmed iRBD patients using normal, fast\u2010paced, and dual\u2010task walking conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 38 participants (24 iRBD, 14 healthy controls) completed the following 5 different walking trials across a pressure sensor carpet: (1) normal pace, (2) fast pace, (3) while counting backward from 100 by 1s, (4) while naming as many animals as possible, (5) while subtracting 7s from 100.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although no gait differences were found between the groups during normal walking, there were significant differences between groups under the fast\u2010paced and dual\u2010task gait conditions. Specifically, in response to the dual tasking, healthy controls widened their step width without changing step width variability, whereas iRBD patients did not widen their step width but, rather, significantly increased their step width variability. Similarly, changes between the groups were observed during fast\u2010paced walking wherein the iRBD patients demonstrated greater step length asymmetry when compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates that iRBD patients have subtle gait impairments, which likely reflect early progressive degeneration in brainstem regions that regulate both REM sleep and gait coordination. Such gait assessments may be useful as a diagnostic preclinical screening tool for future fulminant gait abnormalities for trials of disease\u2010preventive agents. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27780","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T12:54:05Z","timestamp":1561553645000},"page":"1374-1380","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Subtle gait and balance impairments occur in idiopathic rapid eye movement sleep behavior disorder"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8488-2295","authenticated-orcid":false,"given":"Kaylena A.","family":"Ehgoetz Martens","sequence":"first","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Sleep and Circadian Group (Centre for Sleep &amp; Chronobiology [CIRUS]), Woolcock Institute of Medical Research University of Sydney and Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-0488","authenticated-orcid":false,"given":"Elie","family":"Matar","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Sleep and Circadian Group (Centre for Sleep &amp; Chronobiology [CIRUS]), Woolcock Institute of Medical Research University of Sydney and Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Hall","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Phillips","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"School of Social Sciences and Psychology Western Sydney University  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Y. Y.","family":"Szeto","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Gouelle","sequence":"additional","affiliation":[{"name":"ProtoKinetics  Havertown Pennsylvania USA"},{"name":"Laboratory Performance Sant\u00e9 Metrologie, Soci\u00e9t\u00e9, UFR STAPS (Unit for Teaching and Research \u2010 Sciences and Technics for Physical Activities and Sports)  Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald R.","family":"Grunstein","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Sleep and Circadian Group (Centre for Sleep &amp; Chronobiology [CIRUS]), Woolcock Institute of Medical Research University of Sydney and Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0422-8398","authenticated-orcid":false,"given":"Glenda M.","family":"Halliday","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J. G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"ForeFront Research Team, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Parkinson's Disease Research Clinic, Brain and Mind Centre University of Sydney  Sydney Australia"},{"name":"Sleep and Circadian Group (Centre for Sleep &amp; Chronobiology [CIRUS]), Woolcock Institute of Medical Research University of Sydney and Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00057-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.174748"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70054-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws093"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls255"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25653"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170149"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2017.0643"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.5.724"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.04.021"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.10.020"},{"key":"e_1_2_8_13_1","first-page":"1","article-title":"The relationships between mild cognitive impairment and phenotype in Parkinson's disease","volume":"1","author":"Szeto JYY","year":"2015","journal-title":"NPJ Park Dis"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2016.12.023"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijtr.2018.25.6.272"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.01.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200002)47:2<218::AID-ANA12>3.0.CO;2-#"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70213-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25545"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25534"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.01.041"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.178"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/27.1.49"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.11138\/FNeur\/2017.32.1.028"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00034.2015"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-010-2469-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2012.05.019"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073597"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.1.72"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg270"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0775-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-007-0955-7"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26720"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.12.017"},{"key":"e_1_2_8_35_1","article-title":"Objective arm swing analysis in early\u2010stage Parkinson's disease using an RGB\u2010D camera (Kinect \u00ae)","author":"Ospina BM","journal-title":"J Park Dis."}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.27780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.27780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:04:24Z","timestamp":1760954664000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.27780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/mds.27780"],"URL":"https:\/\/doi.org\/10.1002\/mds.27780","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]},"assertion":[{"value":"2019-03-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}