{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T20:35:50Z","timestamp":1785875750798,"version":"3.56.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T00:00:00Z","timestamp":1563494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies that have investigated the potential of in vivo abnormal \u03b1\u2010synuclein deposits as a pathological biomarker for PD included few participants and reported different diagnostic accuracies. Here, we aimed to confirm the diagnostic value of in vivo \u03b1\u2010synuclein deposits in PD through a systematic review and meta\u2010analysis, with special emphasis on determining the tissue most suitable for examination and assessing whether anti\u2010native \u03b1\u2010synuclein or anti\u2010phosphorylated \u03b1\u2010synuclein antibodies should be used. Databases were searched on December 30, 2018. We finally included 41 case\u2010control studies that examined in vivo tissue samples using anti\u2010native \u03b1\u2010synuclein or anti\u2010phosphorylated \u03b1\u2010synuclein antibody in PD patients and controls. Using a univariate random\u2010effects model, pooled sensitivity and specificity (95% confidence interval) of anti\u2010native \u03b1\u2010synuclein antibody were 0.54 (0.49\u20100.60) and 0.72 (0.68\u20100.76) for the gastrointestinal tract and 0.76 (0.60\u20100.89) and 0.60 (0.43\u20100.74) for the skin. Pooled sensitivity and specificity (95% confidence interval) of anti\u2010phosphorylated \u03b1\u2010synuclein antibody were 0.43 (0.37\u20100.48) and 0.82 (0.78\u20100.86) for the gastrointestinal tract, 0.76 (0.69\u20100.82) and 1.00 (0.98\u20101.00) for the skin, 0.42 (0.26\u20100.59) and 0.94 (0.84\u20100.99) for the minor salivary glands, and 0.66 (0.51\u20100.79) and 0.96 (0.86\u20101.00) for the submandibular glands. Although ubiquitous heterogeneity between the included studies should be noted when interpreting our results, our analyses demonstrated the following: (1) in vivo \u03b1\u2010synuclein immunoreactivity has the potential as a pathological biomarker for PD; (2) anti\u2010phosphorylated \u03b1\u2010synuclein antibody consistently has higher specificity than anti\u2010native \u03b1\u2010synuclein antibody; and (3) skin biopsy examination using anti\u2010phosphorylated \u03b1\u2010synuclein antibody has the best diagnostic accuracy, although feasibility remains an important issue. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.27794","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T10:15:22Z","timestamp":1563531322000},"page":"1452-1463","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Value of in vivo \u03b1\u2010synuclein deposits 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