{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:18:46Z","timestamp":1791584326085,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO247"],"award-info":[{"award-number":["KFO247"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigates the association between pallidal low\u2010frequency activity and motor sign severity in dystonia after chronic deep brain stimulation for several months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Local field potentials were recorded in 9 dystonia patients at 5 timepoints (T1\u2013T5) during an OFF\u2010stimulation period of 5 to 7 hours in parallel with clinical assessment using Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale. A linear mixed effects model was used to investigate the potential association of motor signs with local field potential activity in the low frequency (3\u201312 Hz) and beta range (13\u201330 Hz).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant association of Burke\u2010Fahn\u2010Marsden Dystonia Rating Scale scores with low\u2010frequency activity (3\u201312 Hz; b = 4.4; standard error = 1.5, degrees of freedom\u2009=\u200943, <jats:italic>P<\/jats:italic>\u2009=\u20090.006, 95% confidence interval, 1.3\u20137.5), but not beta activity (13\u201330 Hz) was revealed within participants across timepoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low\u2010frequency activity is associated with dystonic motor sign severity, even months after chronic deep brain stimulation. Our findings corroborate the pathophysiological role of low\u2010frequency activity in dystonia and highlight the potential utility as a biomarker for adaptive neuromodulation. \u00a9 2019 Charit\u00e9. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson andMovement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27838","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T12:18:45Z","timestamp":1567599525000},"page":"1734-1739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Pallidal low\u2010frequency activity in dystonia after cessation of long\u2010term deep brain stimulation"],"prefix":"10.1002","volume":"34","author":[{"given":"Ute","family":"Scheller","sequence":"first","affiliation":[{"name":"Charit\u00e9, Universit\u00e4tsmedizin Berlin Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-8250","authenticated-orcid":false,"given":"Roxanne","family":"Lofredi","sequence":"additional","affiliation":[{"name":"Charit\u00e9, Universit\u00e4tsmedizin Berlin Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-0801","authenticated-orcid":false,"given":"Bernadette C.M.","family":"van Wijk","sequence":"additional","affiliation":[{"name":"Charit\u00e9, Universit\u00e4tsmedizin Berlin Campus Mitte, Movement Disorders and Neuromodulation Unit, Department of Neurology  Berlin Germany"},{"name":"Integrative Model\u2010Based Cognitive Neuroscience Research Unit, Department of Psychology University of Amsterdam  Amsterdam the Netherlands"},{"name":"Wellcome Centre for Human Neuroimaging University 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