{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:19:37Z","timestamp":1789773577493,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (NRF) grant funded by the Minister of Science, ICT and Future Planning","award":["2017M3C7A1029485"],"award-info":[{"award-number":["2017M3C7A1029485"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Minister of Science, ICT and Future Planning","award":["2017R1A2B2012280"],"award-info":[{"award-number":["2017R1A2B2012280"]}]},{"name":"National Research Foundation of Korea (NRF) grant funded by the Minister of Science, ICT and Future Planning","award":["NRF-2014R1A2A2A04003858"],"award-info":[{"award-number":["NRF-2014R1A2A2A04003858"]}]},{"name":"SNUH Research Fund","award":["04-2018-0550 (2018-1265)"],"award-info":[{"award-number":["04-2018-0550 (2018-1265)"]}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although previous research provides insight into the role of neuroinflammation in idiopathic REM sleep behavior disorder, the association of this disorder with peripheral blood inflammatory markers remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate inflammatory cytokines in plasma samples in patients with idiopathic rapid eye movement sleep behavior disorder and to explore whether these markers are associated with prodromal symptoms of \u03b1\u2010synucleinopathies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected plasma from patients with polysomnographically confirmed idiopathic rapid eye movement sleep behavior disorder without parkinsonism or dementia (n = 54) and from healthy controls (n = 56). The following cytokines were measured: interleukin\u20101\u03b2, interleukin\u20102, interleukin\u20106, interleukin\u201010, and tumor necrosis factor\u2010\u03b1. The idiopathic REM sleep behavior disorder patients underwent sleep, motor, cognitive, olfactory, and autonomic testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The anti\u2010inflammatory cytokine, interleukin\u201010, levels in the idiopathic rapid eye movement sleep behavior disorder group were significantly upregulated compared to the control group (<jats:italic>P<\/jats:italic> = 0.022), but this difference did not withstand Bonferroni correction. The other proinflammatory cytokine levels did not differ between the groups. No correlation was found between the cytokine levels and any clinical variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data do not provide evidence supporting the role of peripheral inflammation in idiopathic rapid eye movement sleep behavior disorder. However, considering the limited statistical power because of the small sample size, further large\u2010scale longitudinal studies with a broader spectrum of cytokines are needed to clarify this issue. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27841","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T02:07:14Z","timestamp":1569895634000},"page":"1739-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Peripheral Blood Inflammatory Cytokines in Idiopathic REM Sleep Behavior Disorder"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-9180","authenticated-orcid":false,"given":"Ryul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital, Seoul National University, College of Medicine  Seoul 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Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Won","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital, Seoul National University, College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Won","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine  Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Keimyung University Dongsan Medical Center  Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine  Suwon 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