{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:12:22Z","timestamp":1790770342257,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001595","name":"Dystonia Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Abnormal sensory processing, including temporal discrimination threshold, has been described in various dystonic syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate visual sensory processing in DYT\u2010<jats:italic>SGCE<\/jats:italic> and identify its structural correlates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>DYT\u2010<jats:italic>SGCE<\/jats:italic> patients without DBS (DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010non\u2010DBS) and with DBS (DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010DBS) were compared to healthy volunteers in three tasks: a temporal discrimination threshold, a movement orientation discrimination, and movement speed discrimination. Response times attributed to accumulation of sensory visual information were computationally modelized, with \u03bc parameter indicating sensory mean growth rate. We also identified the structural correlates of behavioral performance for temporal discrimination threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010non\u2010DBS, 13 DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010DBS, and 25 healthy volunteers were included in the study. In DYT\u2010<jats:italic>SGCE\u2010<\/jats:italic>DBS, the discrimination threshold was higher in the temporal discrimination threshold (<jats:italic>P<\/jats:italic>\u2009=\u20090.024), with no difference among the groups in other tasks. The sensory mean growth rate (\u03bc) was lower in DYT\u2010<jats:italic>SGCE<\/jats:italic> in all three tasks (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), reflecting a slower rate of sensory accumulation for the visual information in these patients independent of DBS. Structural imaging analysis showed a thicker left primary visual cortex (<jats:italic>P<\/jats:italic>\u2009=\u20090.001) in DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010non\u2010DBS compared to healthy volunteers, which also correlated with lower \u03bc in temporal discrimination threshold (<jats:italic>P<\/jats:italic>\u2009=\u20090.029). In DYT\u2010<jats:italic>SGCE<\/jats:italic>\u2010non\u2010DBS, myoclonus severity also correlated with a lower \u03bc in the temporal discrimination threshold task (<jats:italic>P<\/jats:italic>\u2009=\u20090.048) and with thicker V1 on the left (<jats:italic>P<\/jats:italic>\u2009=\u20090.022).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In DYT\u2010<jats:italic>SGCE<\/jats:italic>, we showed an alteration of the visual sensory processing in the temporal discrimination threshold that correlated with myoclonus severity and structural changes in the primary visual cortex. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27857","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T02:08:07Z","timestamp":1569895687000},"page":"151-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Visual 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