{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:20:54Z","timestamp":1790079654413,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001543","name":"Neurological Foundation of New Zealand","doi-asserted-by":"publisher","award":["1511CF"],"award-info":[{"award-number":["1511CF"]}],"id":[{"id":"10.13039\/501100001543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Subthalamic nucleus deep brain stimulation (STN\u2010DBS) is an effective therapy for selected Parkinson's disease patients with motor fluctuations, but can adversely affect speech and axial symptoms. The use of short pulse width (PW) has been shown to expand the therapeutic window acutely, but its utility in reducing side effects in chronic STN\u2010DBS patients has not been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effect of short PW settings using 30\u2010\u03bcs with conventional 60\u2010\u03bcs settings on stimulation\u2010induced dysarthria in Parkinson's disease patients with previously implanted STN\u2010DBS systems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010center, double\u2010blind, randomized crossover trial, we assigned 16 Parkinson's disease patients who had been on STN\u2010DBS for a mean of 6.5\u2009years and exhibited moderate dysarthria to 30\u2010\u03bcs or 60\u2010\u03bcs settings for 4\u2009weeks followed by the alternative PW setting for a further 4\u2009weeks. The primary outcome was difference in dysarthric speech measured by the Sentence Intelligibility Test between study baseline and the 2 PW conditions. Secondary outcomes included motor, nonmotor, and quality of life measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in the Sentence Intelligibility Test scores between baseline and the 2 treatment conditions (<jats:italic>P<\/jats:italic> = 0.25). There were also no differences noted in motor, nonmotor, or quality of life scores. The 30\u2010\u03bcs settings were well tolerated, and adverse event rates were similar to those at conventional PW settings. Post hoc analysis indicated that patients with dysarthria and a shorter duration of DBS may be improved by short PW stimulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Short PW settings using 30 \u03bcs did not alter dysarthric speech in chronic STN\u2010DBS patients. A future study should evaluate whether patients with shorter duration of DBS may be helped by short PW settings. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27863","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T02:13:59Z","timestamp":1569896039000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Short Versus Conventional Pulse\u2010Width Deep Brain Stimulation in Parkinson's Disease: A Randomized Crossover Comparison"],"prefix":"10.1002","volume":"35","author":[{"given":"Viswas","family":"Dayal","sequence":"first","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London Institute of Neurology  London United Kingdom"},{"name":"Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery  London United 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Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilan","family":"Athauda","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London Institute of Neurology  London United Kingdom"},{"name":"Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-4946","authenticated-orcid":false,"given":"Ludvic","family":"Zrinzo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London Institute of Neurology  London United Kingdom"},{"name":"Unit of Functional Neurosurgery, National Hospital for Neurology and Neurosurgery  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harith","family":"Akram","sequence":"additional","affiliation":[{"name":"Department of 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