{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:15:06Z","timestamp":1791983706404,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008539","name":"CurePSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008539","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HO 2402\/11\u20101"],"award-info":[{"award-number":["HO 2402\/11\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category \u201cprobable 4\u2010repeat (4R)\u2010tauopathy\u201d for joint clinical diagnosis of progressive supranuclear palsy and corticobasal degeneration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To validate the accuracy of these clinical criteria for \u201cprobable 4R\u2010tauopathy\u201d to predict underlying 4R\u2010tauopathy pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnostic accuracy for 4R\u2010tauopathies according to the established criteria was estimated retrospectively in autopsy\u2010confirmed patients with progressive supranuclear palsy and corticobasal degeneration (grouped as 4R\u2010tauopathies), and Parkinson's disease, multiple system atrophy, and frontotemporal lobar degeneration (grouped as non\u20104R\u2010tauopathies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 250 cases with progressive supranuclear palsy (N = 195) and corticobasal degeneration (N = 55) and with and non\u20104R\u2010tauopathies (N = 161). Sensitivity and specificity of \u201cprobable 4R\u2010tauopathy\u201d was 10% and 99% in the first year and 59% and 88% at final record.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The new diagnostic category \u201cprobable 4R\u2010tauopathy\u201d showed high specificity and may be suitable for the recruitment of patients with progressive supranuclear palsy and corticobasal degeneration into therapeutic trials targeting 4R\u2010tauopathy. The low sensitivity underpins the need for diagnostic biomarkers. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27872","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T02:09:22Z","timestamp":1569895762000},"page":"171-176","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Validation of the Movement Disorder Society Criteria for the Diagnosis of 4\u2010Repeat Tauopathies"],"prefix":"10.1002","volume":"35","author":[{"given":"Gesine","family":"Respondek","sequence":"first","affiliation":[{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max\u2010Joseph","family":"Grimm","sequence":"additional","affiliation":[{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Piot","sequence":"additional","affiliation":[{"name":"Department of Neurology Technische Universit\u00e4t M\u00fcnchen  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Arzberger","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"},{"name":"Center for Neuropathology and Prion Research Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[{"name":"Parkinson's Disease &amp; Movement Disorders Unit, Hospital Cl\u00ednic\/August Pi i Sunyer Biomedical Research Institute (IDIBAPS)\/Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas(CIBERNED)\/European Reference Network for Rare Neurological Diseases\/Institut de Neuroci\u00e8ncies, Maeztu center Universitat de Barcelona  Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Englund","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Neurology Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie W.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Division of Neurology, Royal University Hospital University of Saskatchewan  Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Gelpi","sequence":"additional","affiliation":[{"name":"Neurological Tissue Bank and Neurology Department, Hospital Cl\u00ednic de Barcelona Universitat de Barcelona, IDIBAPS, Centres de Recerca de Catalunya (CERCA)  Barcelona Catalonia Spain"},{"name":"Institute of Neurology Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Roeber","sequence":"additional","affiliation":[{"name":"Center for Neuropathology and Prion Research Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Giese","sequence":"additional","affiliation":[{"name":"Center for Neuropathology and Prion Research Ludwig\u2010Maximilians\u2010University Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[{"name":"Frontotemporal Degeneration Center, Department of Neurology University of Pennsylvania  Philadelphia Pennsylvania 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Tayaranian MarvianA BrendelM et al. Four\u2010repeat tauopathies [published online ahead of print June 22 2019]. 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