{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:58:34Z","timestamp":1793951914075,"version":"4.8.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melatonin may reduce REM\u2010sleep behavior disorder (RBD) symptoms in Parkinson's disease (PD), though robust clinical trials are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the efficacy of prolonged\u2010release (PR) melatonin for RBD in PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group trial with an 8\u2010week intervention and 4\u2010week observation pre\u2010 and postintervention (ACTRN12613000648729). Thirty PD patients with rapid eye movement sleep behavior disorder were randomized to 4 mg of prolonged\u2010release melatonin (Circadin) or matched placebo, ingested orally once\u2010daily before bedtime. Primary outcome was the aggregate of rapid eye movement sleep behavior disorder incidents averaged over weeks 5 to 8 of treatment captured by a weekly diary. Data were included in a mixed\u2010model analysis of variance (n = 15 per group).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences between groups at the primary endpoint (3.4 events\/week melatonin vs. 3.6 placebo; difference, 0.2; 95% confidence interval = \u22123.2 to 3.6; <jats:italic>P<\/jats:italic> =\u20090.92). Adverse events included mild headaches, fatigue, and morning sleepiness (n = 4 melatonin; n = 5 placebo).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prolonged\u2010release melatonin 4 mg did not reduce rapid eye movement sleep behavior disorder in PD. \u00a9 2019 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27886","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T23:18:36Z","timestamp":1572563916000},"page":"344-349","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Melatonin for Rapid Eye Movement Sleep Behavior Disorder in Parkinson's disease: A Randomised Controlled Trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Moran","family":"Gilat","sequence":"first","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"ForeFront Parkinson's Disease Research Clinic Brain and Mind Centre, The University of Sydney  Sydney Australia"},{"name":"Research Group for Neurorehabilitation (eNRGy), Department of Rehabilitation Sciences, KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Coeytaux Jackson","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"Department of Neurology University Hospitals of Geneva  Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel S.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Hammond","sequence":"additional","affiliation":[{"name":"ForeFront Parkinson's Disease Research Clinic Brain and Mind Centre, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna E.","family":"Mullins","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Hall","sequence":"additional","affiliation":[{"name":"ForeFront Parkinson's Disease Research Clinic Brain and Mind Centre, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard A.M.","family":"Fang","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon J.","family":"Yee","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith K.H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron R.","family":"Grunstein","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"Department of Respiratory and Sleep Medicine Royal Prince Alfred Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J. G.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Woolcock Institute of Medical Research, The University of Sydney  Sydney Australia"},{"name":"ForeFront Parkinson's Disease Research Clinic Brain and Mind Centre, The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.09.014"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0016-5"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.157"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.27717"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2019.04.029"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119383"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(199905)14:3<507::AID-MDS1021>3.0.CO;2-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2010.00848.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.09.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2016.06.005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488893"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2018.08.008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2001.00854.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1389-9457(03)00072-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.09.018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170523094938"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.753"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.281053"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2010.02.011"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.5464"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00006-0"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.02.016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.01.004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205011666140302195648"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.226.177"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl363"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5796"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5464"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.9179"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31826866f8"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.05.004"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27886","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.27886","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.27886","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:53:44Z","timestamp":1760957624000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.27886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/mds.27886"],"URL":"https:\/\/doi.org\/10.1002\/mds.27886","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,31]]},"assertion":[{"value":"2019-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}