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Patient\u2010reported physical function outcome measures in HD have shown cross\u2010sectional evidence of validity, but responsiveness has not yet been assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluates the responsiveness of the Huntington Disease Health\u2010Related Quality of Life (HDQLIFE) and the Quality of Life in Neurological Disorders (Neuro\u2010QoL) physical function measures in persons with HD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 347 participants completed baseline and at least 1 follow\u2010up (12\u2010month and 24\u2010month) measure (HDQLIFE Chorea, HDQLIFE Swallowing Difficulties, HDQLIFE Speech Difficulties, Neuro\u2010QoL Upper Extremity Function, and\/or Neuro\u2010QoL Lower Extremity Function). Of the participants that completed the baseline assessment, 338 (90.9%) completed the 12\u2010month assessment, and 293 (78.8%) completed the 24\u2010month assessment. Standardized response means and general linear models evaluated whether the physical function measures were responsive to self\u2010reported and clinician\u2010rated change over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Small to moderate effect sizes for the standardized response means supported 12\u2010month and 24\u2010month responsiveness of the HDQLIFE and Neuro\u2010QoL measures for those with either self\u2010reported or clinician\u2010rated declines in function. General linear models supported 12\u2010month and 24\u2010month responsiveness for all HRQOL measures relative to self\u2010reported declines in health, but generally only 24\u2010month responsiveness was supported relative to clinician\u2010rated declines in function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longitudinal analyses indicate that the HDQLIFE and the Neuro\u2010QoL physical function measures are sensitive to change over time in individuals with HD. Thus, these scales exhibit evidence of responsiveness and may be useful outcome measures in future clinical trials. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27908","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T03:53:06Z","timestamp":1573703586000},"page":"326-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["HDQLIFE and Neuro\u2010QoL Physical Function Measures: Responsiveness in Persons with Huntington's Disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Noelle E.","family":"Carlozzi","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R.","family":"Boileau","sequence":"additional","affiliation":[{"name":"Department of Physical 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