{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:00:47Z","timestamp":1780988447821,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>PINK1<\/jats:italic> mutations are likely to affect mitochondrial function. The objective of this study was to study brain mitochondrial function in patients with early\u2010onset Parkinson's disease, with or without <jats:italic>PINK1<\/jats:italic> mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated brain intracellular pH, mitochondrial activity, and energetics with functional magnetic resonance spectroscopy in patients with early\u2010onset Parkinson's disease with <jats:italic>PINK1<\/jats:italic> mutations (n = 10), early\u2010onset Parkinson's disease without <jats:italic>PINK1<\/jats:italic> mutations (n = 10), and healthy sex\u2010 and age\u2010matched subjects (n = 20). We measured peak areas of phosphocreatine and beta adenosine triphosphate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The EOPD\u2010 group had normal PCr + \u03b2ATP contents at rest (<jats:italic>P<\/jats:italic> = NS) and under activation (<jats:italic>P<\/jats:italic> = NS), but reduced contents during recovery (<jats:italic>P<\/jats:italic> &lt; 0.001). The EOPD+ group had abnormal PCr + \u03b2ATP contents at rest (<jats:italic>P<\/jats:italic> &lt; 0.001) and during activation (<jats:italic>P<\/jats:italic> &lt; 0.001); during recovery, the contents only partially recovered (<jats:italic>P<\/jats:italic> &lt; 0.001). Brain intracellular pH alterations were more severe with EOPD+ than with EOPD\u2212.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Brain mitochondrial impairments were similar in early\u2010onset Parkinson's disease without <jats:italic>PINK1<\/jats:italic> mutations and late\u2010onset Parkinson's disease. However, mitochondrial impairments were more severe in early\u2010onset Parkinson's disease with <jats:italic>PINK1<\/jats:italic> mutations. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27946","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T01:59:46Z","timestamp":1578016786000},"page":"504-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Brain Mitochondrial Impairment in Early\u2010Onset Parkinson's Disease With or Without <i>PINK1<\/i> Mutation"],"prefix":"10.1002","volume":"35","author":[{"given":"Mario","family":"Rango","sequence":"first","affiliation":[{"name":"Excellence Center for Advanced MR Techniques and Parkinson' s Disease Center, Neurology Unit Fondazione IRCCS C\u00e0 Granda Maggiore Policlinico Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Dossi","sequence":"additional","affiliation":[{"name":"Excellence Center for Advanced MR Techniques and Parkinson' s Disease Center, Neurology Unit Fondazione IRCCS C\u00e0 Granda Maggiore Policlinico Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Squarcina","sequence":"additional","affiliation":[{"name":"Excellence Center for Advanced MR Techniques and Parkinson' s Disease Center, Neurology Unit Fondazione IRCCS C\u00e0 Granda Maggiore Policlinico Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Bonifati","sequence":"additional","affiliation":[{"name":"Excellence Center for Advanced MR Techniques and Parkinson' s Disease Center, Neurology Unit Fondazione IRCCS C\u00e0 Granda Maggiore Policlinico Hospital, University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410320721"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6392-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70411-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02514.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2015.244"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.06.009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12501"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.10.030"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13731"},{"key":"e_1_2_8_12_1","unstructured":"KorosC SimitsiA StefanisL.Genetics of Parkinson's Disease: Genotype\u2013Phenotype Correlations. 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