{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:46:27Z","timestamp":1790999187762,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T00:00:00Z","timestamp":1577145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013368","name":"Deutsche Akademie der Naturforscher Leopoldina - Nationale Akademie der Wissenschaften","doi-asserted-by":"publisher","award":["LDS 2016\u201008"],"award-info":[{"award-number":["LDS 2016\u201008"]}],"id":[{"id":"10.13039\/501100013368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["P50 NS 071675"],"award-info":[{"award-number":["P50 NS 071675"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>An ideal imaging biomarker for a neurodegenerative disorder should be able to measure abnormalities in the earliest stages of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated metabolic network changes in two independent cohorts of drug\u2010na\u00efve Parkinson's disease (PD) patients who have not been exposed to dopaminergic medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We scanned 85 de novo, drug\u2010na\u00efve PD patients and 85 age\u2010matched healthy control subjects from Italy (n = 96) and the United States (n = 74) with [<jats:sup>18<\/jats:sup>F]\u2010fluorodeoxyglucose PET. All patients had clinical follow\u2010ups to verify the diagnosis of idiopathic PD. Spatial covariance analysis was used to identify and validate de novo PD\u2010related metabolic patterns in the Italian and U.S. cohorts. We compared the de novo PD\u2010related metabolic patterns to the original PD\u2010related pattern that was identified in more advanced patients who had been on chronic dopaminergic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>De novo PD\u2010related metabolic patterns were identified in each of the two independent cohorts of drug\u2010na\u00efve PD patients, and each differentiated PD patients from healthy control subjects. Expression values for these disease patterns were elevated in drug\u2010na\u00efve PD patients relative to healthy controls in the identification as well as in each of the validation subgroups. The two de novo PD\u2010related metabolic patterns were topographically very similar to each other and to the original PD\u2010related pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Reproducible PD\u2010related patterns are expressed in de novo, drug\u2010na\u00efve PD patients. In PD, disease\u2010related metabolic patterns have stereotyped topographies that develop independently of chronic levodopa treatment. \u00a9 2019 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27960","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T04:34:58Z","timestamp":1577162098000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Metabolic Network Abnormalities in Drug\u2010Na\u00efve Parkinson's Disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Katharina A.","family":"Schindlbeck","sequence":"first","affiliation":[{"name":"Center for Neurosciences The Feinstein Institutes for Medical Research  Manhasset New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaia","family":"Lucas\u2010Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Methods 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