{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:16:21Z","timestamp":1769721381192,"version":"3.49.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008001","name":"Universit\u00e4t zu K\u00f6ln","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although deep brain stimulation of the globus pallidus internus (GPi\u2010DBS) is an established treatment for many forms of dystonia, including generalized as well as focal forms, its effects on brain (dys\u2010)function remain to be elucidated, particularly for focal and segmental dystonia. Clinical response to GPi\u2010DBS typically comes with some delay and lasts up to several days, sometimes even weeks, once stimulation is discontinued.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigated how neural activity during rest and motor activation is affected by GPi\u2010DBS while excluding the potential confound of altered feedback as a result of therapy\u2010induced differences in dystonic muscle contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two groups of patients with focal or segmental dystonia were included in the study: 6 patients with GPi\u2010DBS and 8 without DBS (control group). All 14 patients had cervical dystonia. Using H<jats:sub>2<\/jats:sub><jats:sup>15<\/jats:sup>O PET, regional cerebral blood flow was measured at rest and during a motor task performed with a nondystonic hand.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In patients with GPi\u2010DBS (stimulation ON and OFF), activity at rest was reduced in a prefrontal network, and during the motor task, sensorimotor cortex activity was lower than in patients without DBS. Within\u2010group contrasts (tapping &gt; rest) showed less extensive task\u2010induced motor network activation in GPi\u2010DBS patients than in non\u2010DBS controls. Reduced sensorimotor activation amounted to a significant group\u2010by\u2010task interaction only in the stimulation ON state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings support previous observations in generalized dystonia that suggested that GPi\u2010DBS normalizes dystonia\u2010associated sensorimotor and prefrontal hyperactivity, indicating similar mechanisms in generalized and focal or segmental dystonia. Evidence is provided that these effects extend into the OFF state, which was not previously demonstrated by neuroimaging. \u00a9 2020 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27970","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T08:10:31Z","timestamp":1578643831000},"page":"629-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pallidal Deep Brain Stimulation Reduces Sensorimotor Cortex Activation in Focal\/Segmental Dystonia"],"prefix":"10.1002","volume":"35","author":[{"given":"Andrea","family":"Greuel","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital of Giessen and Marburg  Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Amande M.","family":"Pauls","sequence":"additional","affiliation":[{"name":"Department of Neurology Helsinki University Central Hospital  Helsinki Finland"},{"name":"Department of Clinical Neurosciences (Neurology) University of Helsinki  Helsinki Finland"},{"name":"BioMag Laboratory, Helsinki University Hospital Medical Imaging Center University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Koy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine and University Hospital Cologne, University of Cologne  Cologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"S\u00fcdmeyer","sequence":"additional","affiliation":[{"name":"Department of Neurology Ernst\u2010von\u2010Bergmann Klinikum  Potsdam 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