{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:01:33Z","timestamp":1775181693125,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the relationships between the motor phenotype and the presence of specific neuropsychiatric and neuropsychological disorders in patients with early motor\u2010manifest Huntington's disease (HD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the Enroll\u2010HD study, 3,505 individuals with HD who had \u22645\u2009years of motor symptoms were classified based on the predefined parkinsonism\/chorea index into chorea\u2010dominant (n = 1125), parkinsonism\u2010dominant (n = 867), and mixed\u2010motor phenotype (n = 1513) groups. An analysis was performed on the results of the short Problem Behaviors Assessment. This test assesses patients for neuropsychiatric disorders such as depression, irritability\/aggression, apathy, obsessive\u2010compulsive behaviors, and psychosis as well as cognitive disorders by using neuropsychological tests such as the Stroop Interference test, Trail Making Test Part A and B, letter fluency, Symbol Digit Modality test, and animal fluency test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In these early motor\u2013manifest HD individuals, motor phenotype was associated with neuropsychiatric and cognitive changes. Independent of the age of motor onset, motor duration and severity, CAG repeat expansion, and medication use, the parkinsonism\u2010dominant group had more severe neuropsychiatric disorders (depression, apathy, obsessive\u2010compulsive behaviors, and psychosis) and poorer performance on all cognitive tests than those patients in the mixed\u2010motor phenotype and chorea\u2010dominant groups. The patients in the chorea\u2010dominant group had less apathy and depression than those in the mixed\u2010motor phenotype group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the early stage of motor\u2010manifest HD, parkinsonism\u2010dominant patients appear to have more severe neuropsychiatric disturbances and more cognitive impairments than those HD patients with chorea\u2010dominant and mixed\u2010motor phenotypes. Future studies should explore the brain mechanisms of these disorders and the possible treatments. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.27980","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T07:42:36Z","timestamp":1578642156000},"page":"781-788","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Early\u2010Motor Phenotype Relates to Neuropsychiatric and Cognitive Disorders in Huntington's Disease"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-7577","authenticated-orcid":false,"given":"Parunyou","family":"Julayanont","sequence":"first","affiliation":[{"name":"Division of Behavioral and Cognitive Neurology, Department of Neurology University of Florida College of Medicine  Gainesville Florida 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