{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:17Z","timestamp":1787063357133,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sporadic degenerative ataxia patients fall into 2 major groups: multiple system atrophy with predominant cerebellar ataxia (MSA\u2010C) and sporadic adult\u2010onset ataxia (SAOA). Both groups have cerebellar volume loss, but little is known about the differential involvement of gray and white matter in MSA\u2010C when compared with SAOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to identify structural differences of brain gray and white matter between both patient groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used magnetic resonance imaging to acquire T1\u2010weighted images and diffusion tensor images from 12 MSA\u2010C patients, 31 SAOA patients, and 55 healthy controls. Magnetic resonance imaging data were analyzed with voxel\u2010based\u2010morphometry, tract\u2010based spatial statistics, and tractography\u2010based regional diffusion tensor images analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Whole\u2010brain and cerebellar\u2010focused voxel\u2010based\u2010morphometry analysis showed gray matter volume loss in both patient groups when compared with healthy controls, specifically in the cerebellar areas subserving sensorimotor functions. When compared with controls, the SAOA and MSA\u2010C patients showed white matter loss in the cerebellum, whereas brainstem white matter was reduced only in the MSA\u2010C patients. The tract\u2010based spatial statistics revealed reduced fractional anisotropy within the pons and cerebellum in the MSA\u2010C patients both in comparison with the SAOA patients and healthy controls. In addition, tractography\u2010based regional analysis showed reduced fractional anisotropy along the corticospinal tracts in MSA\u2010C, but not SAOA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Although in our cohort extent and distribution of gray and white matter loss were similar between the MSA\u2010C and SAOA patients, magnetic resonance imaging data showed prominent microstructural white matter involvement in the MSA\u2010C patients that was not present in the SAOA patients. Our findings highlight the significance of microstructural white matter changes in the differentiation between both conditions. \u00a9 2020 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.27987","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T07:37:30Z","timestamp":1580283450000},"page":"816-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Prominent White Matter Involvement in Multiple System Atrophy of Cerebellar Type"],"prefix":"10.1002","volume":"35","author":[{"given":"Jennifer","family":"Faber","sequence":"first","affiliation":[{"name":"Clinical Research, German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Giordano","sequence":"additional","affiliation":[{"name":"Clinical Research, German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Clinical Research, German Center for Neurodegenerative Diseases  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kindler","sequence":"additional","affiliation":[{"name":"Clinical Research, German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[{"name":"Clinical Research, German Center for Neurodegenerative Diseases  Bonn Germany"},{"name":"Department of Neurology University Hospital Bonn  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Acosta\u2010Cabronero","sequence":"additional","affiliation":[{"name":"Tenoke Ltd.  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