{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:59:25Z","timestamp":1789570765428,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI\u2010LB) compared with prodromal Alzheimer's disease (MCI\u2010AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 73 MCI\u2010LB patients (12% female; 68\u2009\u00b1\u20096\u2009years; Mini Mental State Examination, 27\u2009\u00b1\u20092) and 124 MCI\u2010AD patients (48% female; 68\u2009\u00b1\u20097\u2009years; Mini Mental State Examination, 27\u2009\u00b1\u20092) from the Amsterdam Dementia Cohort. Follow\u2010up was available for 61 MCI\u2010LB patients and all MCI\u2010AD patients (3\u2009\u00b1\u20092\u2009years). We evaluated dementia with Lewy bodies core features, neuropsychiatric symptoms, caregiver burden (Zarit caregiver burden interview), MRI, apolipoprotein genotype, and cerebrospinal fluid biomarkers (tau\/A\u03b2\n                      <jats:sub>1\u201342<\/jats:sub>\n                      ratio). Longitudinal outcome measures included cognitive slopes (memory, attention, executive functions, and language and visuospatial functions) and time to dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Parkinsonism was the most frequently present core feature in MCI\u2010LB (69%). MCI\u2010LB patients more often had neuropsychiatric symptoms and scored higher on ZARIT when compared with the MCI\u2010AD patients. Linear mixed models showed that at baseline, MCI\u2010LB patients performed worse on nonmemory cognitive domains, whereas memory performance was worse in MCI\u2010AD patients. Over time, MCI\u2010LB patients declined faster on attention, whereas MCI\u2010AD patients declined faster on the Mini Mental State Examination and memory. Cox proportional hazards regressions showed that in the MCI\u2010LB patients, lower attention (hazard ratio [HR] = 1.6; 95% confidence interval [CI], 1.1\u20132.3) and more posterior cortical atrophy (HR = 3.0; 95% CI, 1.5\u20135.8) predicted shorter time to dementia. In the MCI\u2010AD patients, worse performance on memory (HR = 1.1; 95% CI, 1.0\u20131.2) and executive functions (HR = 1.3; 95% CI, 1.0\u20131.6) were independently associated with time to Alzheimer's dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      MCI\u2010LB patients have distinct neuropsychiatric and cognitive profiles with prominent decline in attention when compared with MCI\u2010AD patients. Our results highlight the importance of early diagnosis because symptoms already have an impact in the prodromal stages. \u00a9 2020 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.27997","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T02:30:16Z","timestamp":1581474616000},"page":"859-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-073X","authenticated-orcid":false,"given":"Marleen","family":"van de 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