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There have also been recent examples of applications in epilepsy, chronic pain, and neuropsychiatric conditions. Innovations in neuroimaging technology have been driving connectomics, an emerging whole\u2010brain network approach to neuroscience. Two rising techniques are functional connectivity profiling and structural connectivity profiling. Functional connectivity profiling explores the operational relationships between multiple regions of the brain with respect to time and stimuli. Structural connectivity profiling approximates physical connections between different brain regions through reconstruction of axonal fibers. Through these techniques, complex relationships can be described in various disease states, such as PD, as well as in response to therapy, such as DBS. These advances have expanded our understanding of human brain function and have provided a partial in vivo glimpse into the underlying brain circuits underpinning movement and other disorders. This comprehensive review will highlight the contemporary concepts in brain connectivity as applied to DBS, as well as introduce emerging considerations in movement disorders. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.28045","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T23:48:56Z","timestamp":1586735336000},"page":"741-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["A Comprehensive Review of Brain Connectomics and Imaging to Improve Deep Brain Stimulation Outcomes"],"prefix":"10.1002","volume":"35","author":[{"given":"Joshua K.","family":"Wong","sequence":"first","affiliation":[{"name":"Fixel Institute for Neurological Diseases University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik H.","family":"Middlebrooks","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeet S.","family":"Grewal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Fixel Institute for Neurological Diseases University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Hess","sequence":"additional","affiliation":[{"name":"Fixel Institute for Neurological Diseases University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Okun","sequence":"additional","affiliation":[{"name":"Fixel Institute for Neurological Diseases University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53497-2.00006-1"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300962"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70048-6"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2402638"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0010042"},{"key":"e_1_2_15_8_1","first-page":"32","article-title":"Thalamus studies I\u2010III","volume":"50","author":"Vogt C","year":"1941","journal-title":"J Psychol Neurol"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn893"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00697.2006"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.11.019"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2012.00015"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.01.020"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2003.10.033"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-200401000-00006"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.055"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(65)90126-3"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.09.034"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2016.00045"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(94)00008-D"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww182"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.07.012"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5641"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.01.008"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24974"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.09.005"},{"key":"e_1_2_15_29_1","unstructured":"BucknerRL RoffmanJL SmollerJW. 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