{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:25:25Z","timestamp":1790450725654,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"KAKENHI","award":["17K15805"],"award-info":[{"award-number":["17K15805"]}]},{"name":"KAKENHI","award":["19K17148"],"award-info":[{"award-number":["19K17148"]}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess the relationship between nigrostriatal magnetic susceptibility and dopamine transporter abnormality and their associations with behavioral and cognitive impairments in patients with Parkinson's disease (PD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this case\u2010control study, we enrolled 41 patients with PD and 20 age\u2010matched healthy controls. All participants underwent global physical and cognitive assessments, 3\u2010Tesla brain magnetic resonance imaging including quantitative susceptibility mapping (QSM; iron deposition measure), and <jats:sup>123<\/jats:sup>I\u2010N\u2010v\u2010fluoropropyl\u20102b\u2010carbomethoxy\u20103b\u2010(4\u2010iodophenyl) nortropane single\u2010photon emission computed tomography (dopamine transporter measure). We subdivided the striatum into the putamen, caudate nucleus, and nucleus accumbens and measured the nigrostriatal QSM values and dopamine transporter\u2013specific binding ratios using an atlas\u2010based approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with PD had higher QSM values in the substantia nigra and subdivisions of the striatum than did the healthy controls. The striatal dopamine transporter\u2013specific binding ratios were not correlated with the QSM values of the substantia nigra but were inversely correlated with those of the striatum (putamen, <jats:italic>r<\/jats:italic> = \u22120.478, <jats:italic>P<\/jats:italic> = 0.009; caudate nucleus, <jats:italic>r<\/jats:italic> = \u22120.462, <jats:italic>P<\/jats:italic> = 0.011). The QSM values of the putamen were positively correlated with motor parkinsonism scores (Movement Disorder Society Unified Parkinson's Disease Rating Scale, <jats:italic>r<\/jats:italic> = 0.505, <jats:italic>P<\/jats:italic> = 0.003), and those of the caudate nucleus were negatively correlated with cognitive impairment scores (Montreal Cognitive Assessment, <jats:italic>r<\/jats:italic> = \u22120.525, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that striatal iron accumulations were correlated with dopaminergic deficits and neurophysiological signs in patients with PD, highlighting the potential of QSM as an auxiliary biomarker for parkinsonism and cognitive dysfunction. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28077","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T15:56:42Z","timestamp":1588694202000},"page":"1396-1405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Magnetic Susceptibility Associates With Dopaminergic Deficits and Cognition in Parkinson's Disease"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6521-0784","authenticated-orcid":false,"given":"Yuto","family":"Uchida","sequence":"first","affiliation":[{"name":"Department of Neurology and Neuroscience Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Neurology Toyokawa City Hospital  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Kan","sequence":"additional","affiliation":[{"name":"Radiological and Medical Laboratory Sciences Nagoya 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