{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:59:31Z","timestamp":1788184771767,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:00:00Z","timestamp":1588982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["97,800"],"award-info":[{"award-number":["97,800"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The recurrent hemizygous 22q11.2 deletion associated with 22q11.2 deletion syndrome has been identified as a genetic risk factor for early\u2010onset PD. However, little is known about early motor signs in this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined the presence, severity and possible factors associated with parkinsonism in adults with 22q11.2 deletion syndrome and without PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared motor signs between 82 adults with 22q11.2 deletion syndrome and 25 healthy controls, using the MDS\u2010UPDRS part III, and three\u2010dimensional motion\u2010tracker technology to quantify components of bradykinesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median MDS\u2010UPDRS part III total and bradykinesia subscores were significantly higher in 22q11.2 deletion syndrome (median age: 26\u2009years; range, 17\u201365) than in controls (<jats:italic>P<\/jats:italic> = 0.000; <jats:italic>P<\/jats:italic> = 0.000, respectively). Age was a significant contributor to bradykinesia subscore (<jats:italic>B<\/jats:italic> = 0.06; <jats:italic>P<\/jats:italic> = 0.01) and to the electronic bradykinesia component, velocity (<jats:italic>B<\/jats:italic> = \u20130.02; <jats:italic>P<\/jats:italic> = 0.000); psychotic illness did not significantly impact these analyses. In 22q11.2 deletion syndrome, MDS\u2010UPDRS\u2013defined bradykinesia was present in 18.3%, rigidity in 14.6%, and rest tremor in 12.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Parkinsonian motor signs appear to be common and age related in 22q11.2 deletion syndrome. Longitudinal studies are needed to investigate possible symptom progression to PD. \u00a9 2020 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28080","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:25:56Z","timestamp":1589012756000},"page":"1239-1245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>Age\u2010Related<\/scp> Parkinsonian Signs in Microdeletion 22q11.2"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0593-1539","authenticated-orcid":false,"given":"Erik","family":"Boot","sequence":"first","affiliation":[{"name":"The Dalglish Family 22q Clinic University Health Network  Toronto Ontario Canada"},{"name":"Advisium,'s Heeren Loo Zorggroep  Amersfoort The Netherlands"},{"name":"Department of Psychiatry &amp; Neuropsychology Maastricht University  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry Q.","family":"Mentzel","sequence":"additional","affiliation":[{"name":"Innova, Psychiatric Centre GGz Centraal  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa D.","family":"Palmer","sequence":"additional","affiliation":[{"name":"The Dalglish Family 22q Clinic University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter N.","family":"van Harten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry &amp; Neuropsychology Maastricht University  Maastricht The Netherlands"},{"name":"Innova, Psychiatric Centre GGz Centraal  Amersfoort The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie","family":"Marras","sequence":"additional","affiliation":[{"name":"The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital and University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[{"name":"The Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic Toronto Western Hospital and University of Toronto  Toronto Ontario Canada"},{"name":"Division of Neurology, Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-7279","authenticated-orcid":false,"given":"Anne S.","family":"Bassett","sequence":"additional","affiliation":[{"name":"The Dalglish Family 22q Clinic University Health Network  Toronto Ontario Canada"},{"name":"Clinical Genetics Research Program, and Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Department of Psychiatry, Division of Cardiology, Department of Medicine, and Toronto General Research Institute University Health Network  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario 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