{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:35:40Z","timestamp":1790674540031,"version":"4.1.0"},"reference-count":196,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Huntington's disease is an autosomal\u2010dominant, neurodegenerative disorder caused by a CAG repeat expansion in exon\u20101 of the huntingtin gene. Alterations in cholesterol metabolism and distribution have been reported in Huntington's disease, including abnormal interactions between mutant huntingtin and sterol regulatory element\u2010binding proteins, decreased levels of apolipoprotein E\/cholesterol\/low\u2010density lipoprotein receptor complexes, and alterations in the synthesis of ATP\u2010binding cassette transporter A1. Plasma levels of 24S\u2010hydroxycholestrol, a key intermediary in cholesterol metabolism and a possible marker in neurodegenerative diseases, decreased proportionally to the degree of caudate nucleus atrophy. The interaction of mutant huntingtin with sterol regulatory element\u2010binding proteins is of particular interest given that sterol regulatory element\u2010binding proteins play a dual role: They take part in lipid and cholesterol metabolism, but also in the inflammatory response that induces immune cell migration as well as toxic effects, particularly in astrocytes. This work summarizes current evidence on the metabolic and immune implications of sterol regulatory element\u2010binding protein dysregulation in Huntington's disease, highlighting the potential use of drugs that modulate these alterations. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.28089","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T04:35:36Z","timestamp":1589517336000},"page":"1113-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dysregulated Brain Cholesterol Metabolism Is Linked to Neuroinflammation in Huntington's Disease"],"prefix":"10.1002","volume":"35","author":[{"given":"Edith","family":"Gonz\u00e1lez\u2010Guevara","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cMVS\u201d  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Departamento de Neurolog\u00eda y Enfermedades Neuro\u2010Infecciosas Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cMVS\u201d  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"P\u00e9rez\u2010Severiano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cMVS\u201d  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1487","authenticated-orcid":false,"given":"Juan Carlos","family":"Mart\u00ednez\u2010Lazcano","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofarmacolog\u00eda Molecular y Nanotecnolog\u00eda Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda \u201cMVS\u201d  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198511000-00003"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90346-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8710"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059581"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.5.813"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64565"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2011.28"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.09.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm170"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/60.2.161"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3668"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215593"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1984.tb12701.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5545.1354"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2001.00686.x"},{"key":"e_1_2_11_19_1","first-page":"271","article-title":"Role of cholesterol in synapse formation and function","volume":"2003","author":"Pfrieger FW","year":"1610","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.02.006"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3705"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00042"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr0700753"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080178"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1231"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24445"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-200104000-00003"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313828200"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.060681"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2009.07.013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195152227.001.0001"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.003"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2016-8-1-58-73"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R400004-JLR200"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.09.015"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2940635"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05917.x"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405345200"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1971.tb09604.x"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0690-07.2007"},{"key":"e_1_2_11_41_1","first-page":"237","article-title":"BDNF function and intracellular signaling in neurons","volume":"25","author":"Numakawa T","year":"2010","journal-title":"Histol Histopathol"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.10.004"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1139\/o92-065"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1994.63020634.x"},{"key":"e_1_2_11_45_1","first-page":"896","article-title":"Isoprenoids, small GTPases and Alzheimer's disease","volume":"2010","author":"Hooff GP","year":"1801","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2011.06.005"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90407-7"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011099798"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M081240"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00489.x"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15158.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00018-0"},{"key":"e_1_2_11_53_1","first-page":"261","article-title":"Molecular characterization of the detergent\u2010insoluble cholesterol\u2010rich membrane microdomain (raft) of the central nervous system","volume":"2003","author":"Maekawa S","year":"1610","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"e_1_2_11_54_1","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.1016\/S0021-9258(19)39282-8","article-title":"Cholesterol is required for the construction of the sodium and chloride\u2010coupled, gamma\u2010aminobutyric acid transporter from rat brain","volume":"265","author":"Shouffani A","year":"1990","journal-title":"J Biol Chem"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2003.11.005"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1042\/AN20100007"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3539-10.2011"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-150181"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(00)65005-5"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.10.036"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-000-0616-9"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2620"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.005"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.326405"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2009.02.001"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21605"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.035"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200293-JLR200"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04901.x"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601019200"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.072407.103859"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr7006076"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000120374.59826.1b"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2009.02.005"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)02277-7"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.17.1953"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.01.188"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2011.132"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2014.12.018"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3355-05.2005"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn212"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2011.03.025"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9944com"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439225"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(00)65005-5"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12286"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.07.004"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0917-10.2010"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.03.013"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81362-8"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80095-9"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.24.11603"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2004.09.018"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00591-9"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.06.019"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505413"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0055-y"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi800209h"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz174"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.16.6.0835"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300044200"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02183.x"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.066399"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/549627"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.32048"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028502"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.02.032"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002577200"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10668"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2016.1147683"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2019.1584692"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.06.012"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-017-0733-2"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132528"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21029"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911503106"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.083287"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2014"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3722"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.11.030"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3668"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80513-9"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5334.1990"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2008.09.004"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90111-M"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00615-3"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.91"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02516.x"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080178"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7170"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.08.011"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211851"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211103"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0072-1"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.679043"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.677286"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.002352"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151948"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.015"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.11.013"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.162"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-002-0916-0"},{"key":"e_1_2_11_143_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0022-3565(24)39169-4","article-title":"Cerivastatin improves survival of mice with lipopolysaccharide\u2010induced sepsis","volume":"294","author":"Ando H","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2006.077"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.03.042"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06912.x"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2007.0369"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.10.023"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2010.10.005"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu058"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12902"},{"key":"e_1_2_11_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.07.031"},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/762506"},{"key":"e_1_2_11_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.12.022"},{"key":"e_1_2_11_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.04.043"},{"key":"e_1_2_11_156_1","first-page":"449","article-title":"ABC transporters in adaptive immunity","volume":"2015","author":"Seyffer F","year":"1850","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_11_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.03.030"},{"key":"e_1_2_11_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27591"},{"key":"e_1_2_11_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2014.04.004"},{"key":"e_1_2_11_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods6100092"},{"key":"e_1_2_11_161_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg271"},{"key":"e_1_2_11_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18736"},{"key":"e_1_2_11_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.05.011"},{"key":"e_1_2_11_164_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8261-y"},{"key":"e_1_2_11_165_1","first-page":"4012","article-title":"Curcumin dietary supplementation ameliorates disease phenotype in an animal model of Huntington's disease","volume":"28","author":"Elifani F","year":"2019","journal-title":"Hum Mol Genet"},{"key":"e_1_2_11_166_1","first-page":"445","article-title":"The protective effect of curcumin on Abeta induced aberrant cell cycle reentry on primary cultured rat cortical neurons","volume":"16","author":"Wang J","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_11_167_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90428.2008"},{"key":"e_1_2_11_168_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.135.2.190"},{"key":"e_1_2_11_169_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509993667"},{"key":"e_1_2_11_170_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.7.1289"},{"key":"e_1_2_11_171_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.115.306376"},{"key":"e_1_2_11_172_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19107"},{"key":"e_1_2_11_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.01.003"},{"key":"e_1_2_11_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-012-0965-0"},{"key":"e_1_2_11_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00361-0"},{"key":"e_1_2_11_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-015-0635-1"},{"key":"e_1_2_11_177_1","first-page":"368","article-title":"Antioxidant and lipid\u2010regulating effects of probucol combined with atorvastatin in patients with acute coronary syndrome","volume":"7","author":"Guo YS","year":"2015","journal-title":"J Thorac Dis"},{"key":"e_1_2_11_178_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000199"},{"key":"e_1_2_11_179_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3020345"},{"key":"e_1_2_11_180_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2528-7"},{"key":"e_1_2_11_181_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv290"},{"key":"e_1_2_11_182_1","first-page":"568","article-title":"Olesoxime, a cholesterol\u2010like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis","volume":"13","author":"Martin LJ","year":"2010","journal-title":"Drugs"},{"key":"e_1_2_11_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2012.02.013"},{"key":"e_1_2_11_184_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8663-3"},{"key":"e_1_2_11_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22593"},{"key":"e_1_2_11_186_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12939"},{"key":"e_1_2_11_187_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv384"},{"key":"e_1_2_11_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2018.07.019"},{"key":"e_1_2_11_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl434"},{"key":"e_1_2_11_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2008.10.007"},{"key":"e_1_2_11_191_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-25-08733.2003"},{"key":"e_1_2_11_192_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2010.01157.x"},{"key":"e_1_2_11_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.08.019"},{"key":"e_1_2_11_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24406"},{"key":"e_1_2_11_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24428"},{"key":"e_1_2_11_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.02.009"},{"key":"e_1_2_11_197_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25107"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.28089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28089","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28089","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:44:29Z","timestamp":1760971469000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":196,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/mds.28089"],"URL":"https:\/\/doi.org\/10.1002\/mds.28089","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,15]]},"assertion":[{"value":"2019-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}