{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:54:54Z","timestamp":1790830494815,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T00:00:00Z","timestamp":1592179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204005\/Z\/16\/Z"],"award-info":[{"award-number":["204005\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Huntington\u2019s disease is a genetic neurodegenerative disorder. White matter alterations have recently been identified as a relevant pathophysiological feature of Huntington\u2019s disease, but their etiology and role in disease pathogenesis and progression remain unclear. Increasing evidence suggests that white matter changes in this disorder are attributed to alterations in myelin\u2010associated biological processes. This review first discusses evidence from neurochemical studies lending support to the demyelination hypothesis of Huntington\u2019s disease, demonstrating aberrant myelination and changes in oligodendrocytes in the Huntington\u2019s brain. Next, evidence from neuroimaging studies is reviewed, the limitations of the described methodologies are discussed, and suggested interpretations of findings from published studies are challenged. Although our understanding of Huntington\u2019s associated pathological changes in the brain will increasingly rely on neuroimaging techniques, the shortcomings of these methodologies must not be forgotten. Advances in magnetic resonance imaging techniques and tissue modeling will enable a better in vivo, longitudinal characterization of the biological properties of white matter microstructure. This in turn will facilitate identification of disease\u2010related biomarkers and the specification of outcome measures in clinical trials. \u00a9 2020 The Authors.\n                    <jats:italic>Movement Disorders<\/jats:italic>\n                    published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.\n                  <\/jats:p>","DOI":"10.1002\/mds.28109","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T03:44:10Z","timestamp":1592192650000},"page":"1302-1311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["A Critical Review of White Matter Changes in Huntington\u2019s Disease"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-3330","authenticated-orcid":false,"given":"Chiara","family":"Casella","sequence":"first","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre School of Psychology, Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Lipp","sequence":"additional","affiliation":[{"name":"Department of Neurophysics Max Planck Institute for Human Cognitive and Brain Sciences  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Rosser","sequence":"additional","affiliation":[{"name":"School of Biosciences Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek K","family":"Jones","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre School of Psychology, Cardiff University  Cardiff United Kingdom"},{"name":"Mary MacKillop Institute for Health Research Australian Catholic University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Metzler\u2010Baddeley","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre School of Psychology, Cardiff University  Cardiff United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.128728"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.12.026"},{"key":"e_1_2_6_4_1","first-page":"A15","article-title":"A43 Intrinsic mutant HTT\u2010mediated defects in oligodendroglia cells contribute to myelin deficits and behavioural abnormalities in huntington disease","volume":"89","author":"Bardile CF","year":"2018","journal-title":"J Neurol Neurosurg 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