{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:50:04Z","timestamp":1792403404935,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07559\u20103"],"award-info":[{"award-number":["2013\/07559\u20103"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The natural history of neurodegeneration in spinocerebellar ataxia type 3\/Machado Joseph disease is still unclear. Here, we built a long\u2010term longitudinal clinical and neuroimaging study to address this point.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010three patients with spinocerebellar ataxia type 3\/Machado Joseph disease and 22 healthy controls underwent 3T MRI twice 5.0\u2009years apart. T1 and diffusion tensor imaging sequences were obtained. We used T1 multiatlas, diffusion tensor imaging multiatlas, SpineSeg, and CERES\u2010SUIT for cerebral gray and white matter, spinal cord and cerebellar analyses, respectively. Clinical severity was assessed with scale for assessment and rating of ataxia. Analysis of covariance evaluated longitudinal between\u2010group changes. Effect sizes were calculated for each significant result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Progressive volumetric abnormalities were most evident in the cerebellum (Lobule X and Crus II; effect size, 2.0), followed by the basal ganglia (effect size, 0.7). The cerebellar peduncles had the largest white\u2010matter diffusivity changes (effect size, 1.29). Scale for assessment and rating of ataxia\u2013related effect size was 0.82. We failed to identify progressive spinal cord abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Longitudinal changes in spinocerebellar ataxia type 3\/Machado Joseph disease are more evident in the cerebellum and connections, followed by the basal ganglia. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28113","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T09:30:58Z","timestamp":1591695058000},"page":"1679-1684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["A\n                    <scp>5\u2010Year<\/scp>\n                    Longitudinal Clinical and Magnetic Resonance Imaging Study in Spinocerebellar Ataxia Type 3"],"prefix":"10.1002","volume":"35","author":[{"given":"Camila Callegari","family":"Piccinin","sequence":"first","affiliation":[{"name":"School of Medical Sciences University of Campinas  Campinas Brazil"},{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Junqueira Ribeiro","family":"Rezende","sequence":"additional","affiliation":[{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"},{"name":"Department of Neurology University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Levi Ribeiro","family":"de Paiva","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Cury","family":"Moys\u00e9s","sequence":"additional","affiliation":[{"name":"School of Medical Sciences University of Campinas  Campinas Brazil"},{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Rolim Muro","family":"Martinez","sequence":"additional","affiliation":[{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"},{"name":"Department of Neurology University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cendes","sequence":"additional","affiliation":[{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"},{"name":"Department of Neurology University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Marcondes Cavalcante","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Brazilian Institute of Neuroscience and Neurotechnology (BRAINN)  Campinas Brazil"},{"name":"Department of Neurology University of Campinas  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2009.08.012"},{"key":"e_1_2_7_3_1","unstructured":"Paulson H. Spinocerebellar Ataxia Type 3. In: Adam MP Ardinger HH Pagon RA et al. editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington Seattle; 1993\u20102020. Available from:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1196\/"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25297"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2011.00614.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws369"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.06.011"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000219042.60538.92"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.10.042"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.01.045"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096985"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181d1a6c9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25451"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1363"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048-016-0473-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822e7ca0"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmds.28113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28113","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:23:30Z","timestamp":1760959410000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/mds.28113"],"URL":"https:\/\/doi.org\/10.1002\/mds.28113","archive":["Portico"],"relation":{},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,9]]},"assertion":[{"value":"2019-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}