{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:27:35Z","timestamp":1788326855590,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\"Assessorat f\u00fcr Gesundheit\", Province of Bolzano, Italy"},{"name":"\"Gesundheitsbezirk Bruneck\", Province of Bolzano, Italy"},{"name":"\"Pustertaler Verein zur Pr\u00e4vention von Herz- und Hirngefaesserkrankungen\", Province of Bolzano, Italy"},{"name":"Tiroler Wissenschaftsf\u00f6rderung","award":["UNI-0404\/2245"],"award-info":[{"award-number":["UNI-0404\/2245"]}]},{"name":"Austrian Society of Neurology"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying individuals at risk of developing Parkinson's disease (PD) is critical to define target populations for future neuroprotective trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to apply the PREDICT\u2010PD algorithm of risk indicators for PD in a prospective community\u2010based study (the Bruneck study), representative of the general elderly population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PREDICT\u2010PD risk scores were calculated based on risk factor assessments obtained at baseline (2005, n = 574 participants). Cases of incident PD were identified at 5\u2010year and 10\u2010year follow\u2010ups. Participants with PD or secondary parkinsonism at baseline were excluded (n = 35). We analyzed the association of log\u2010transformed risk scores with the presence of well\u2010established markers as surrogates for PD risk at baseline and with incident PD at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 participants with incident PD were identified during follow\u2010up (11 after 5\u2009years and 9 after 10\u2009years). Baseline PREDICT\u2010PD risk scores were associated with incident PD with odds ratios of 2.09 (95% confidence interval, 1.35\u20133.25; <jats:italic>P<\/jats:italic> =\u20090.001) after 5\u2009years and of 1.95 (1.36\u20132.79; <jats:italic>P<\/jats:italic> &lt;\u20090.001) after 10\u2009years of follow\u2010up per doubling of risk scores. In addition, higher PREDICT\u2010PD scores were significantly correlated with established PD risk markers (olfactory dysfunction, signs of rapid eye movement sleep behavior disorder and motor deficits) and significantly associated with higher probability for prodromal PD according to the Movement Disorder Society research criteria at baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The PREDICT\u2010PD score was associated with an increased risk for incident PD in our sample and may represent a useful first screening step in future algorithms aiming to identify cases of prodromal PD. \u00a9 2020 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28127","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T09:43:55Z","timestamp":1591177435000},"page":"1658-1662","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Application of a Simple Parkinson's Disease Risk Score in a Longitudinal <scp>Population\u2010Based<\/scp> Cohort"],"prefix":"10.1002","volume":"35","author":[{"given":"Kathrin","family":"Marini","sequence":"first","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0671-0516","authenticated-orcid":false,"given":"Philipp","family":"Mahlknecht","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck 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Neurology Innsbruck Medical University  Innsbruck Austria"},{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiechl","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck Austria"},{"name":"VASCage, Research Centre on Vascular Ageing and Stroke  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Willeit","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Rungger","sequence":"additional","affiliation":[{"name":"Department of Neurology Hospital of Bruneck  Bruneck Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3027-5497","authenticated-orcid":false,"given":"Alastair J.","family":"Noyce","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London Institute of Neurology, University College London  London United Kingdom"},{"name":"Preventive Neurology Unit Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9872-6680","authenticated-orcid":false,"given":"Anette","family":"Schrag","sequence":"additional","affiliation":[{"name":"Department of Clinical and Movement Neurosciences University College London Institute of Neurology, University College London  London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seppi","sequence":"additional","affiliation":[{"name":"Department of Neurology Innsbruck Medical University  Innsbruck 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