{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:50:53Z","timestamp":1771962653557,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,10]]},"abstract":"Abstract<\/jats:title>Background and Objectives<\/jats:title>MicroRNA (miRNA) changes are observed in PD but remain poorly explored in other \u03b1\u2010synucleinopathies such as MSA.<\/jats:p><\/jats:sec>Methods<\/jats:title>By genome\u2010wide analysis we profiled microRNA expression in serum from 20 MSA cases compared to 40 controls. By qPCR we validated top differentially expressed microRNAs in another sample of 20 MSA and 20 controls. We also assessed the expression of MSA differentially expressed microRNAs in two consecutive sets of 19 and 18 PD patients.<\/jats:p><\/jats:sec>Results<\/jats:title>In the discovery set we identified 25 differentially expressed microRNAs associated with MSA, which are related to prion disease, fatty acid metabolism, and Notch signaling. Among these, we selected nine differentially expressed microRNAs and by qPCR confirmed array findings in a second MSA sample. MicroRNA\u20107641 and microRNA\u2010191 consistently differentiated between MSA and PD.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Serum microRNA changes occur in MSA and may reflect disease\u2010associated mechanisms. We identified two microRNAs which may differentiate MSA from PD. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28143","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T13:29:34Z","timestamp":1595251774000},"page":"1873-1879","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["MicroRNA<\/scp> Deregulation in Blood Serum Identifies Multiple System Atrophy Altered Pathways"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-7528","authenticated-orcid":false,"given":"Alexandra","family":"P\u00e9rez\u2010Soriano","sequence":"first","affiliation":[{"name":"Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders: Clinical and Experimental Research; Department of Neurology Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Institut de Neuroci\u00e8ncies, Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06\/05\/0018\u2010ISCIII) Barcelona Spain"},{"name":"Parkinson's disease & Movement Disorders Unit, Neurology Service Hospital Cl\u00ednic de Barcelona, ERN\u2010RND, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"Bravo","sequence":"additional","affiliation":[{"name":"Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders: Clinical and Experimental Research; Department of Neurology Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Institut de Neuroci\u00e8ncies, Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Soto","sequence":"additional","affiliation":[{"name":"Lab of Parkinson Disease and Other Neurodegenerative Movement Disorders: Clinical and Experimental Research; Department of Neurology Hospital Cl\u00ednic de Barcelona, Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Institut de Neuroci\u00e8ncies, Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Infante","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas (CIBERNED: CB06\/05\/0018\u2010ISCIII) Barcelona Spain"},{"name":"Movement Disorders Unit, Department of Neurology Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria Santander 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