{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:38:49Z","timestamp":1788565129064,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T00:00:00Z","timestamp":1597449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cognitive impairment is common in patients with PD. Core markers of Alzheimer's dementia have been related also to PD dementia, but no disease\u2010specific signature to predict PD dementia exists to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate CSF markers associated with cognition in early PD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A high\u2010throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini\u2010Mental State Examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 69 patients with complete data, 34 had high (\u226590) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (&lt;90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen\u20101, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Kininogen\u20101 levels in CSF may serve as a marker of cognitive impairment in PD. \u00a9 2020 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28192","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T12:36:32Z","timestamp":1597494992000},"page":"2101-2106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Cerebrospinal Fluid Levels of Kininogen\u20101 Indicate Early Cognitive Impairment in Parkinson's Disease"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3328-5746","authenticated-orcid":false,"given":"Ioanna","family":"Markaki","sequence":"first","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[{"name":"Division of Affinity Proteomics, Department of Protein Science KTH\u2010Royal Institute of Technology  SciLifeLab, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Tsitsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Remnest\u00e5l","sequence":"additional","affiliation":[{"name":"Division of Affinity Proteomics, Department of Protein Science KTH\u2010Royal Institute of Technology  SciLifeLab, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"M\u00e5nberg","sequence":"additional","affiliation":[{"name":"Division of Affinity Proteomics, Department of Protein Science KTH\u2010Royal Institute of Technology  SciLifeLab, Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Hertz","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Paslawski","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo","family":"Sorjonen","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Uhl\u00e9n","sequence":"additional","affiliation":[{"name":"Division of Systems Biology, Department of Protein Science KTH\u2010Royal Institute of Technology  SciLifeLab, Stockholm Sweden"},{"name":"Department of Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"Mangone","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique H\u00f4pitaux de Paris, NS\u2010PARK\/FCRIN network, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM  Inserm U 1127, CNRS UMR 7225, Department of Neurology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Assistance Publique H\u00f4pitaux de Paris, NS\u2010PARK\/FCRIN network, Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, ICM  Inserm U 1127, CNRS UMR 7225, Department of Neurology, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Rascol","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique CIC1436, Centre Expert Parkinson de Toulouse, D\u00e9partement Neurosciences et pharmacologie Clinique, NS\u2010PARK\/FCRIN network, NeuroToul COEN Center; 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