{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:18:13Z","timestamp":1787501893390,"version":"build-2736575974"},"reference-count":11,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Movement Disorders Research Fund, Toronto General and Western Hospital Foundation"},{"name":"Parkinson Research Consortium"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study was to assess the 12\u2010week efficacy and safety of oral glycopyrrolate for moderate\u2010to\u2010severe sialorrhea in Parkinson's disease (PD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic moderate\u2010to\u2010severe sialorrhea has a negative impact on quality of life in PD. There is no robust evidence for oral treatments for sialorrhea longer than 1 week.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a 12\u2010week, double\u2010blinded, placebo\u2010controlled, parallel phase II study in patients with PD and Movement Disorder Society\u2013Unified Parkinson's Disease Rating Scale item 2.2\u2009&gt;\u20092. The intervention was glycopyrrolate up to 4.5 mg\/d; the primary outcome was sialorrhea related\u2013disability (Radboud Oral Motor Inventory for Parkinson's Disease\u2013Saliva). We used an intention\u2010to\u2010treat analysis. A\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05 was deemed significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We recruited 28 patients (age, 71.1\u2009\u00b1\u20096.9\u2009years; PD duration, 11.4\u2009\u00b1\u20097.2\u2009years; Radboud Oral Motor Inventory for Parkinson's Disease\u2013Saliva, 22.4\u2009\u00b1\u20095.7). Glycopyrrolate was superior to placebo at 12\u2009weeks in the Radboud Oral Motor Inventory for Parkinson's Disease\u2013Saliva (between\u2010group difference, 5.3; 95% confidence interval, 1.0\u20139.6). Dry mouth was the most common adverse event (glycopyrrolate, n = 6; placebo, n = 2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results support the efficacy of glycopyrrolate to treat sialorrhea\u2010related disability up to 12\u2009weeks and contribute to addressing unmet nonmotor care needs in PD. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28196","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T05:40:41Z","timestamp":1594618841000},"page":"2319-2323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Glycopyrrolate Improves Disability From Sialorrhea in Parkinson's Disease: A\n                    <scp>12\u2010Week<\/scp>\n                    Controlled Trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6973-7479","authenticated-orcid":false,"given":"Tiago A.","family":"Mestre","sequence":"first","affiliation":[{"name":"University of Ottawa Brain and Mind Research Institute  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Parkinson Disease and Movement Disorders Centre, Division of Neurology, Department of Medicine The Ottawa Hospital\/University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-0892","authenticated-orcid":false,"given":"Eliza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Basndwah","sequence":"additional","affiliation":[{"name":"University of Ottawa Brain and Mind Research Institute  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Parkinson Disease and Movement Disorders Centre, Division of Neurology, Department of Medicine The Ottawa Hospital\/University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Ruiz","family":"Lopez","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"},{"name":"University Hospital Fundaci\u00f3n Jimenez Diaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-6755","authenticated-orcid":false,"given":"Lais Machado","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duha Mohammed","family":"Al\u2010Shorafat","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Ottawa Methods Center The Ottawa Hospital Research Institute  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane P.","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University Health Network, Toronto Western Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Grimes","sequence":"additional","affiliation":[{"name":"University of Ottawa Brain and Mind Research Institute  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Parkinson Disease and Movement Disorders Centre, Division of Neurology, Department of Medicine The Ottawa Hospital\/University of Ottawa  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan H.","family":"Fox","sequence":"additional","affiliation":[{"name":"Movement Disorders Clinic Toronto Western Hospital  Toronto Ontario Canada"},{"name":"Krembil Brain Institute, University Health Network  Toronto Ontario Canada"},{"name":"Division of Neurology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5098-2"},{"issue":"11","key":"e_1_2_8_3_1","first-page":"2628","article-title":"Sialorrhea: a management challenge","volume":"69","author":"Hockstein NG","year":"2004","journal-title":"Am Fam 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