{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:25:09Z","timestamp":1790270709704,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009420","name":"Varsinais-Suomen Sairaanhoitopiiri","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data on the epidemiology and prognosis of Wilson's disease are scarce, and no clinical data are available from Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All persons diagnosed and treated for Wilson's disease in Finnish hospitals in 1998 to 2017 were identified. Data were collected from national registries and patient charts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The point prevalence was 0.45\/100,000 (95% confidence interval, 0.29\u20130.67) on December 31, 2017, but no more than 0.35\/100,000 (95% confidence interval, 0.21\u20130.55) among native Finns. Annual incidence was 0.016\/100,000 (95% confidence interval, 0.0093\u20130.026). Median age at diagnosis was 15.8\u2009years (interquartile range, 8.3\u201332.2; range, 3.8\u201348.1\u2009years). Upon presentation, liver damage was observed in 58%, neurological signs and symptoms (most often tremor and dysarthria) in 40%, and 32% of patients were asymptomatic. Patients had poorer long\u2010term survival (hazard ratio, 2.92 for death;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.005) compared with matched controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Wilson's disease is very rare in Finland. Patients have an increased risk of death indicating an unmet treatment need. \u00a9 2020 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28207","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T02:27:21Z","timestamp":1593743241000},"page":"2323-2327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Wilson's Disease in Finland: A Nationwide\n                    <scp>Population\u2010Based<\/scp>\n                    Study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0183-9054","authenticated-orcid":false,"given":"Jussi O.T.","family":"Sipil\u00e4","sequence":"first","affiliation":[{"name":"Clinical Neurosciences University of Turku and Turku University Hospital  Turku Finland"},{"name":"Department of Neurology Siun Sote North Karelia Central Hospital  Joensuu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marja","family":"Hietala","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Turku University Hospital  Turku Finland"},{"name":"Institute of Biomedicine, University of Turku  Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Kyt\u00f6","sequence":"additional","affiliation":[{"name":"Heart Center, Turku University Hospital and University of Turku  Turku Finland"},{"name":"Center for Population Health Research, Turku University Hospital and University of Turku  Turku Finland"},{"name":"Administrative Center, Hospital District of Southwest Finland  Turku 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