{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:51:55Z","timestamp":1791820315285,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psychiatric comorbidities are common and major determinants of quality of life in idiopathic dystonia. Their prevalence estimates from service\u2010based studies are heterogeneous.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We explored the association between idiopathic dystonia and depressive disorders, anxiety disorders, suicide attempts, and death by suicide using Swedish population\u2010based registers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diagnoses of idiopathic dystonia and psychiatric outcomes from inpatient and outpatient specialist services (1997\u20132013) were collected from the National Patient Register and the Cause of Death Register. Familial associations were explored using the Multi\u2010Generation Register. Adjusted logistic regression analyses measured associations with psychiatric disorders in individuals with dystonia compared with general population individuals and their unaffected siblings, as well as in full siblings of individuals with dystonia compared with full siblings of unaffected individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individuals with dystonia were more likely than those without to have a diagnosis of depressive disorder (adjusted odds ratio = 2.00, 95% confidence interval: 1.77\u20132.26), anxiety disorder (adjusted odds ratio = 2.13, 95% confidence interval: 1.90\u20132.39), and suicide attempts\/death by suicide combined (adjusted odds ratio = 1.80, 95% confidence interval: 1.50\u20132.17), with odds higher in most idiopathic dystonia forms. In the full sibling comparison, estimates followed the same pattern, with overall attenuated magnitude. Full siblings of individuals with dystonia had higher likelihood of depressive or anxiety disorders and suicide attempts\/death by suicide combined compared with siblings of individuals without dystonia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Different forms of idiopathic dystonia confirm its association with increased risk for depressive and anxiety disorders and suicide attempts. Familial coaggregation of dystonia and these psychiatric comorbidities supports shared genetic and extragenetic factors. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28257","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T08:45:49Z","timestamp":1600332349000},"page":"2270-2278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Association and Familial Coaggregation of Idiopathic Dystonia With Psychiatric Outcomes"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-0487","authenticated-orcid":false,"given":"Davide","family":"Martino","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustaf","family":"Brander","sequence":"additional","affiliation":[{"name":"Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"},{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"Science for Life Laboratory, Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Svenningsson","sequence":"additional","affiliation":[{"name":"Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"},{"name":"Neuro Division, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet  Stockholm Sweden"},{"name":"School of Medical Sciences, \u00d6rebro University  \u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Fern\u00e1ndez de la Cruz","sequence":"additional","affiliation":[{"name":"Stockholm Health Care Services, Region Stockholm  Stockholm Sweden"},{"name":"Centre for Psychiatry Research, Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03053.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25475"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207729"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"DefazioG JankovicJ GielJL PapapetropoulosS.Descriptive epidemiology of cervical dystonia. 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