{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:27:05Z","timestamp":1790731625654,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Loss of medullary serotonin (5\u2010hydroxytryptamine) neurons has been linked to respiratory disturbances in multiple system atrophy (MSA). Broader 5\u2010hydroxytryptamine dysfunction may contribute to additional motor\/nonmotor symptoms in MSA. The objective of this study was to compare brain 5\u2010hydroxytryptamine<jats:sub>1A<\/jats:sub> receptor binding between MSA and healthy controls. Secondary objectives were to compare 5\u2010hydroxytryptamine<jats:sub>1A<\/jats:sub> receptor binding between MSA and Parkinson's disease (PD) and to assess potential associations with motor\/nonmotor symptoms in MSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>2\u2032\u2010Methoxyphenyl\u2010(N\u20102\u2032\u2010pyridinyl)\u2010<jats:italic>p<\/jats:italic>\u201018F\u2010fluoro\u2010benzamidoethylpiperazine positron emission tomography was performed in matched MSA patients (n = 16), PD patients (n = 15), and healthy controls (n = 18).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>2\u2032\u2010Methoxyphenyl\u2010(N\u20102\u2032\u2010pyridinyl)\u2010<jats:italic>p<\/jats:italic>\u201018F\u2010fluoro\u2010benzamidoethylpiperazine distribution volume ratios were lower in MSA patients versus healthy controls in several brain regions including the caudate, raphe nuclei, thalamus, and brain stem. Distribution volume ratios were also lower in brain stem and amygdala in MSA versus PD. Moderate associations were found between 2\u2032\u2010methoxyphenyl\u2010(N\u20102\u2032\u2010pyridinyl)\u2010<jats:italic>p<\/jats:italic>\u201018F\u2010fluoro\u2010benzamidoethylpiperazine distribution volume ratios and fatigue, pain, and apathy in MSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results demonstrate 5\u2010hydroxytryptamine dysfunction in several brain regions in MSA, which may contribute to fatigue, pain, and apathy. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28295","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T17:21:22Z","timestamp":1600708882000},"page":"246-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Brain <scp>5\u2010HT1A<\/scp> Receptor Binding in Multiple System Atrophy: An [<scp><sup>18<\/sup>F<\/scp>]\u2010<scp>MPPF PET<\/scp> Study"],"prefix":"10.1002","volume":"36","author":[{"given":"Marie","family":"Meyer","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHU de Bordeaux  Bordeaux France"},{"name":"Institut des Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS, UMR 5287, Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lamare","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, CHU de Bordeaux  Bordeaux France"},{"name":"Institut des Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine, CNRS, UMR 5287, Bordeaux University  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Asselineau","sequence":"additional","affiliation":[{"name":"Public Health Department, Clinical Epidemiology Unit Bordeaux University Hospital  Bordeaux 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