{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:41:36Z","timestamp":1792168896739,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The search for valid preclinical biomarkers of cerebellar dysfunction is a key research goal for the upcoming era of early interventional approaches in spinocerebellar ataxias. This study aims to describe novel preclinical biomarkers of subtle gait and postural sway abnormalities in prodromal spinocerebellar ataxia type 2 (pre\u2010SCA2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty pre\u2010SCA2 patients and their matched healthy controls underwent quantitative assessments of gait and postural sway using a wearable sensor\u2010based system and semiquantitative evaluation of cerebellar features by SARA (Scale for the Assessment and Rating of Ataxia) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Quantitative analysis of natural gait showed a significantly larger variability of the swing period, toe\u2010off angle and toe\u2010out angle in pre\u2010SCA2, and larger mean coronal and transverse ranges of motion of the trunk at the lumbar location and of the sagittal range of motion of the trunk at the sternum location compared to controls. During tandem gait, pre\u2010SCA2 subjects showed larger lumbar, trunk, and arm ranges of motion than controls. Postural sway analysis showed excessive body oscillation that was increased in tandem stance. Overall, these abnormalities were detected in pre\u2010SCA2 patients without clinical evidence of abnormalities in SARA. The toe\u2010off angle and swing time variability were significantly correlated with the time to ataxia onset, whereas the toe\u2010off angle and transverse range of motion at trunk position during tandem gait were significantly associated with the SARA score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrates early alteration of gait and postural sway control in prodromal SCA2 using a wearable sensor\u2010based system. This offers new pathophysiological hints into this early disease stage and provides novel potential biomarkers for future clinical trials. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28343","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T10:50:05Z","timestamp":1603795805000},"page":"471-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Prodromal Spinocerebellar Ataxia Type 2 Subjects Have Quantifiable Gait and Postural Sway Deficits"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-2703","authenticated-orcid":false,"given":"Luis","family":"Vel\u00e1zquez\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Clinical Neurophysiology Centre for the Research and Rehabilitation of Hereditary Ataxias  Holgu\u00edn Cuba"},{"name":"Cuban Academy of 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