{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:46Z","timestamp":1792801786104,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","award":["#16048"],"award-info":[{"award-number":["#16048"]}],"id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["VENI grant #91617077"],"award-info":[{"award-number":["VENI grant #91617077"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patients with Parkinson's disease (PD) are very vulnerable to the negative effects of psychological distress: neuropsychiatric symptoms, such as anxiety and depression, are highly prevalent in PD; motor symptoms (such as tremor) typically worsen in stressful situations; and dopaminergic medication is less effective. Furthermore, animal studies of PD suggest that chronic stress may accelerate disease progression. Adequate self\u2010management strategies are therefore essential to reduce the detrimental effects of chronic stress on PD. Mindfulness\u2010based interventions encourage individuals to independently self\u2010manage and adapt to the challenges created by their condition. In PD, emerging clinical evidence suggests that mindfulness\u2010based interventions may reduce psychological distress and improve clinical symptoms, but insight into the underlying mechanisms is lacking. In this viewpoint, we provide a systematic overview of existing mindfulness trials in PD. Furthermore, we discuss the cerebral mechanisms involved in acute and chronic stress, and the impact of mindfulness\u2010based interventions on these networks. In addition, we delineate a hypothetical mechanistic framework of how chronic stress may increase the susceptibility for neuropsychiatric symptoms in PD and may potentially even influence disease progression. We end with offering recommendations for future research. \u00a9 2020 The Authors. <jats:italic>Movement Disorders<\/jats:italic> published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society<\/jats:p>","DOI":"10.1002\/mds.28345","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T10:33:30Z","timestamp":1603449210000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms"],"prefix":"10.1002","volume":"36","author":[{"given":"Anouk","family":"van der Heide","sequence":"first","affiliation":[{"name":"Department of Neurology, Centre of Expertise for Parkinson &amp; Movement Disorders Radboud University Medical Centre  Nijmegen the Netherlands"},{"name":"Donders Institute for Brain, Cognition, and Behavior, Centre for Cognitive 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