{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T11:03:45Z","timestamp":1793703825956,"version":"4.5.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011898","name":"Marianne and Marcus Wallenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011898","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008444","name":"Parkinsonfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008444","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Alzheimer's disease co\u2010pathology is common in dementia with Lewy bodies and Parkinson's disease with dementia (Lewy body disease) and can reliably be detected with positron emission tomography (PET) or cerebrospinal fluid (CSF) biomarkers. Recently developed blood biomarkers are more accessible and less expensive alternatives.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To investigate if plasma phospho\u2010tau217 and phospho\u2010tau181 can detect Alzheimer's pathology in Lewy body disease with dementia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this cross\u2010sectional study we investigated plasma phospho\u2010tau217 and phospho\u2010tau181 in 35 patients with Lewy body disease with dementia. Patients underwent tau\u2010PET imaging (\n 18<\/jats:sup>\n F\u2010RO948).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Plasma phospho\u2010tau217 correlated with plasma phospho\u2010tau181, CSF phospho\u2010tau217 (r\n s<\/jats:sub>\n = 0.68,\n P<\/jats:italic>\n \u2009<\u20090.001), and negatively with CSF \u03b2\u2010amyloid\n 42\/40<\/jats:sub>\n (r\n s<\/jats:sub>\n = \u22120.52,\n P<\/jats:italic>\n = 0.001). Plasma phospho\u2010tau217 and phospho\u2010tau181 correlated with tau\u2010PET signal in the temporal cortex (r\n s<\/jats:sub>\n \u2009>\u20090.56,\n P<\/jats:italic>\n \u2009<\u20090.001) and predicted abnormal tau\u2010PET status and \u03b2\u2010amyloid status (area under the curve > 0.78 and > 0.81, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Plasma phospho\u2010tau might be a useful marker for Alzheimer's co\u2010pathology in Lewy body disease with dementia. \u00a9 2020 The Authors.\n Movement Disorders<\/jats:italic>\n published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mds.28370","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T14:26:20Z","timestamp":1607351180000},"page":"767-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Plasma Phospho\u2010Tau Identifies Alzheimer's Co\u2010Pathology in Patients with Lewy Body Disease"],"prefix":"10.1002","volume":"36","author":[{"given":"Sara","family":"Hall","sequence":"first","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shorena","family":"Janelidze","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Londos","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Leuzy","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund Sweden"},{"name":"Memory Clinic Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[{"name":"Clinical Memory Research Unit, Department of Clinical Sciences Malm\u00f6 Lund University Lund 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