{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T11:12:38Z","timestamp":1781521958788,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005639","name":"Universidade de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome related to multiple underlying pathologies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate if individual brain [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose\u2010positron emission tomography (FDG\u2010PET) patterns could distinguish CBS due to Alzheimer's disease (AD) from other pathologies based on [<jats:sup>11<\/jats:sup>C]Pittsburgh Compound\u2010B (PIB)\u2010PET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients with probable CBS were prospectively evaluated regarding cognitive and movement disorders profile. They underwent FDG\u2010PET and were distributed into groups: likely related to AD (CBS FDG\u2010AD) or likely non\u2010AD (CBS FDG\u2010nonAD) pathology. Thirty patients underwent PIB\u2010PET on a hybrid PET\u2010magnetic resonance imaging equipment to assess their amyloid status. FDG and PIB\u2010PET images were classified individually based on visual and semi\u2010quantitative analysis, blinded to each other. Quantitative group analyses were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CBS FDG\u2010AD group demonstrated worse cognitive performances, mostly concerning attention, memory, visuospatial domains, and displayed more myoclonus and hallucinations. The non\u2010AD metabolic group presented more often limb dystonia, ocular motor dysfunction, motor perseveration, and dysarthria. All patients classified as CBS FDG\u2010AD tested positive at PIB\u2010PET compared to 3 of 20 in the non\u2010AD group. The individual FDG\u2010PET classification demonstrated 76.92% of sensitivity, 100% of specificity and positive predictive value and 88.5% of balanced accuracy to detect positive PIB\u2010PET scans. Individuals with positive and negative PIB\u2010PET showed hypometabolism in posterior temporoparietal areas and in thalamus and brainstem, respectively, mainly contralateral to most affected side, disclosing possible metabolic signatures of CBS variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FDG\u2010PET was useful to predict AD and non\u2010AD CBS variants depicting their specific degeneration patterns, different clinical features, and brain amyloid deposition. \u00a9 2020 International Parkinson and Movement Disorder Society<\/jats:p><\/jats:sec>","DOI":"10.1002\/mds.28373","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T17:12:35Z","timestamp":1605719555000},"page":"651-661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["<scp>FDG\u2010PET<\/scp> Patterns Predict Amyloid Deposition and Clinical Profile in Corticobasal Syndrome"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3565-5328","authenticated-orcid":false,"given":"Jacy Bezerra","family":"Parmera","sequence":"first","affiliation":[{"name":"Department of Neurology Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC\u2010FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5555-4583","authenticated-orcid":false,"given":"Artur Martins","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine (LIM 43) Center of Nuclear Medicine, Institute of Radiology, Hospital das Cl\u00ednicas, Faculdade de Medicina da Universidade de S\u00e3o Paulo (HC\u2010FMUSP)  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9594-292X","authenticated-orcid":false,"given":"Mateus 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