{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:26:54Z","timestamp":1792708014918,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["421887978"],"award-info":[{"award-number":["421887978"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["422182557"],"award-info":[{"award-number":["422182557"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BR4580\/1\u20101"],"award-info":[{"award-number":["BR4580\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy \u2010 ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy \u2010 ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["RO5194\/1\u20101"],"award-info":[{"award-number":["RO5194\/1\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005224","name":"Deutsches Zentrum f\u00fcr Neurodegenerative Erkrankungen","doi-asserted-by":"publisher","award":["DescribePSP Study"],"award-info":[{"award-number":["DescribePSP Study"]}],"id":[{"id":"10.13039\/501100005224","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008483","name":"NOMIS Stiftung","doi-asserted-by":"publisher","award":["FTLD project"],"award-info":[{"award-number":["FTLD project"]}],"id":[{"id":"10.13039\/501100008483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["movementdisorders.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Movement Disorders"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4\u2010repeat tauopathies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The aim of this cross\u2010sectional study was to investigate 18\u2009kDa translocator protein positron emission tomography (PET) as a biomarker for microglial activation in the 4\u2010repeat tauopathies corticobasal degeneration and progressive supranuclear palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Specific binding of the 18\u2009kDa translocator protein tracer\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010GE\u2010180 was determined by serial PET during pharmacological depletion of microglia in a 4\u2010repeat tau mouse model. The 18\u2009kDa translocator protein PET was performed in 30 patients with corticobasal syndrome (68\u2009\u00b1\u20099\u2009years, 16 women) and 14 patients with progressive supranuclear palsy (69\u2009\u00b1\u20099\u2009years, 8 women), and 13 control subjects (70\u2009\u00b1\u20097\u2009years, 7 women). Group comparisons and associations with parameters of disease progression were assessed by region\u2010based and voxel\u2010wise analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Tracer binding was significantly reduced after pharmacological depletion of microglia in 4\u2010repeat tau mice. Elevated 18\u2009kDa translocator protein labeling was observed in the subcortical brain areas of patients with corticobasal syndrome and progressive supranuclear palsy when compared with controls and was most pronounced in the globus pallidus internus, whereas only patients with corticobasal syndrome showed additionally elevated tracer binding in motor and supplemental motor areas. The 18\u2009kDa translocator protein labeling was not correlated with parameters of disease progression in corticobasal syndrome and progressive supranuclear palsy but allowed sensitive detection in patients with 4\u2010repeat tauopathies by a multiregion classifier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our data indicate that\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010GE\u2010180 PET detects microglial activation in the brain of patients with 4\u2010repeat tauopathy, fitting to predilection sites of the phenotype. The 18\u2009kDa translocator protein PET has a potential for monitoring neuroinflammation in 4\u2010repeat tauopathies. \u00a9 2020 The Authors.\n                      <jats:italic>Movement Disorders<\/jats:italic>\n                      published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mds.28395","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T06:41:39Z","timestamp":1606459299000},"page":"883-894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["In Vivo Assessment of Neuroinflammation in\n                    <scp>4\u2010Repeat<\/scp>\n                    Tauopathies"],"prefix":"10.1002","volume":"36","author":[{"given":"Carla","family":"Palleis","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Sauerbeck","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonie","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrella","family":"Morenas\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anika","family":"Finze","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Nitschmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Ruch\u2010Rubinstein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Eckenweber","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Biechele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Blume","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endy","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"B\u00f6tzel","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-5383","authenticated-orcid":false,"given":"Adrian","family":"Danek","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris\u2010Stephan","family":"Rauchmann","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Munich, LMU Munich  Munich Germany"},{"name":"Center for Neuropathology and Prion Research University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"St\u00f6cklein","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Unterrainer","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie L.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy University of Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"},{"name":"Department of Nuclear Medicine University of Bern, Inselspital  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"},{"name":"Chair of Metabolic Biochemistry Biomedical Center, Faculty of Medicine, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Herms","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"},{"name":"Center for Neuropathology and Prion Research University Hospital of Munich, LMU Munich  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"},{"name":"Department of Psychiatry and Psychotherapy University Hospital, LMU Munich  Munich Germany"},{"name":"Ageing Epidemiology Research Unit, School of Public Health Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Haass","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"},{"name":"Department of Nuclear Medicine University of Bern, Inselspital  Bern Switzerland"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital of Munich, Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) Munich  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-6187","authenticated-orcid":false,"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"},{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine University Hospital of Munich, LMU Munich  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2019.101644"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1964.00460160003001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000030"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172158"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00172"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4132"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1769-z"},{"issue":"1","key":"e_1_2_9_10_1","first-page":"21","article-title":"Imaging of neuroinflammation in dementia: a review","volume":"87","author":"Stefaniak J","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0996-15.2015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0296-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20668"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005610"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506123"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27992"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09340.2002"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01883-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.167858"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.195107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"},{"key":"e_1_2_9_22_1","unstructured":"RespondekG KlockgetherT SpottkeA H\u00f6glingerG.German prospective studies on PSP: ProPSP and DESCRIBE\u2010PSP. Poster presented at: Deutscher Kongress f\u00fcr Parkinson und Bewegungsst\u00f6rungen D\u00fcsseldorf;2019.https:\/\/d-nb.info\/1181570069\/34. Accessed on November 15 2020."},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(03)00114-8"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.2526"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1352-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00440"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.10123"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70042-0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02158-2"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.090"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009093"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0301-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12582"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04732-y"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01433-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-4268-4"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.015"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201796516"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01323-8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm104"},{"issue":"2","key":"e_1_2_9_41_1","first-page":"II6\u20131","article-title":"Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration","volume":"246","author":"Dickson DW","year":"1999","journal-title":"J Neurol"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1347-6"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27872"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28011"}],"container-title":["Movement Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28395","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mds.28395","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mds.28395","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:07:51Z","timestamp":1786630071000},"score":1,"resource":{"primary":{"URL":"https:\/\/movementdisorders.onlinelibrary.wiley.com\/doi\/10.1002\/mds.28395"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/mds.28395"],"URL":"https:\/\/doi.org\/10.1002\/mds.28395","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.14.20150243","asserted-by":"object"}]},"ISSN":["0885-3185","1531-8257"],"issn-type":[{"value":"0885-3185","type":"print"},{"value":"1531-8257","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]},"assertion":[{"value":"2020-08-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}